MI-3 (Menin-MLL Inhibitor)

• 常用名: MI-3 (Menin-MLL Inhibitor)
• 英文名: MI-3
• CAS号: 1271738-59-0
• 分子量: 375.555
• 密度: 1.4±0.1 g/cm3
• 沸点: 527.9±60.0 °C at 760 mmHg
• 分子式: C₁₈H₂₅N₅S₂
• 熔点: N/A
• 闪点: 273.1±32.9 °C

MI-3 (Menin-MLL Inhibitor)用途

MI-3 是 Menin-MLL 相互作用抑制剂,IC50为 648 nM。

MI-3 (Menin-MLL Inhibitor)名称

• 中文名: 4-[4-(4,5-二氢-5,5-二甲基-2-噻唑基)-1-哌嗪基]-6-异丙基噻吩并[2,3-d]嘧啶
• 英文名: 4-[4-(5,5-dimethyl-4H-thiazol-2-yl)piperazin-1-yl]-2-isopropyl-th ieno[2,3-d]pyrimidine

MI-3 (Menin-MLL Inhibitor)生物活性

• 描述: MI-3 是 Menin-MLL 相互作用抑制剂,IC50为 648 nM。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Grembecka J, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nature Chemical Biology (2012), 8(3), 277-284.

MI-3 (Menin-MLL Inhibitor)物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 527.9±60.0 °C at 760 mmHg
• 分子式: C₁₈H₂₅N₅S₂
• 分子量: 375.555
• 闪点: 273.1±32.9 °C
• 精确质量: 375.155121
• PSA: 98.16000
• LogP: 3.23
• InChIKey: FUGQNAUKABUDQI-UHFFFAOYSA-N
• SMILES: CC(C)c1cc2c(N3CCN(C4=NCC(C)(C)S4)CC3)ncnc2s1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.713
• 储存条件: -20℃
• 水溶解性: Insuluble (4.5E-3 g/L) (25 ºC)

MI-3 (Menin-MLL Inhibitor)靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：NMR Spectroscopy Assay from US Patent US8993552: "Compositions and methods for treatm... 来源：BindingDB 靶标：N/A External Id：BindingDB_6769_3

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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MI-3 (Menin-MLL Inhibitor)英文别名

• 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine
• 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-isopropylthieno[2,3-d]pyrimidine
• 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-2-isopropylthieno[2,3-d]pyrimidine
• MI-3 (Menin-MLL Inhibitor)
• MI-3