709-55-7

• 常用中文名：乙苯福林
• 常用英文名：Etilefrin
• CAS号：709-55-7
• 分子式：C₁₀H₁₅NO₂
• 分子量：181.23200
• 相关类别： 信号通路 表观遗传学 AMPK
• 发布时间：2018-02-11 08:00:00
• 更新时间：2026-07-16 12:12:11
• 艾替利氟林(3-[2-(乙氨基)-1-羟乙基]苯酚)是一种α肾上腺素能激动剂[2]。艾替利福林也是AMPK激活剂[1]。艾替利氟林可用于体位性低血压的研究[3]。

名称

• 中文名: 乙苯福林
• 英文名: 3-[2-(Ethylamino)-1-hydroxyethyl]phenol
• 中文别名: 依替夫林; 3-[2-(乙胺基)-1-羟基乙基]苯酚; 依替福林
• 英文别名: ETILEFRINE-D5; Arsinous chloride,ethylphenyl; Ethylhrine hydrochloride; Etilhrine; ethylphenylarsine chloride; Aethylphenylarsinchlorid; Etilefrinhydrochlorid; 3-[2-(ethylamino)-1-hydroxyethyl]phenol; S 40; Etilefrin-d5; Aethyl-phenyl-dithiocarbamidsaeure,Ammonium-Salz; Benzenemethanol, .alpha-[(ethylamino)methyl]-3-hydroxy-, hydrochloride; ethyl(phenyl)arsinous chloride; Benzyl alcohol, α-[(ethylamino)methyl]-m-hydroxy- (6CI, 8CI); m-[2-(Ethylamino)-1-hydroxyethyl]phenol; Aethyl-chlor-phenyl-arsin; Aids-001656; AMP-activated protein kinase,Beta Rector,Inhibitor,AMPK activator,Adrenergic Rector,Etilefrine,α adrenergic Agonist,AMPK,postural hypotension,inhibit; α-(m-Hydroxyphenyl)-β-(ethylamino)ethanol; (+-)-Etilefrin; 9 (Hydrochloride); Etilefrin DISCONTINUED, offer E932950; Aethylphenylarsenchlorid; Racemic etilefrine; α-[(Ethylamino)methyl]-m-hydroxybenzyl alcohol; Aids001656; ethyl-chloro-phenyl-arsine; [3H]-(+/-)-Etilefrine; dl-Etilefrin; alpha.-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride; Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy; 2-ethylamino-1-(3-hydroxy-phenyl)-ethanol; Etiladrianol; Arsine,chloroethylphenyl-(6CI,7CI,8CI); Chloroethylphenylarsine; 1-(3-Hydroxyphenyl)-2-(ethylamino)ethanol; ammonium N-ethyl-N-phenyldithiocarbamate; (RS)-etilefrine; ethyl-phenyl-dithiocarbamic acid,ammonium salt; Aethyl-phenyl-chlor-arsin; ethylphenylephrine; N-Ethylnorphenylhrine; Ethylphenylchloroarsine; Ethylphenylhrine; m-Hydroxy-α-(ethylaminomethyl)benzyl alcohol

物化性质

• 密度: 1.127 g/cm3
• 沸点: 351.7ºC at 760 mmHg
• 分子式: C₁₀H₁₅NO₂
• 分子量: 181.23200
• 闪点: 155.5ºC
• 精确质量: 181.11000
• PSA: 52.49000
• LogP: 1.42600
• 折射率: 1.561

生物活性

• 描述: 艾替利氟林(3-[2-(乙氨基)-1-羟乙基]苯酚)是一种α肾上腺素能激动剂[2]。艾替利福林也是AMPK激活剂[1]。艾替利氟林可用于体位性低血压的研究[3]。
• 相关类别:
  信号通路 >> 表观遗传学 >> AMPK
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
• 靶点:

  AMPK

• 体内研究: 艾替利氟林(0.1 mg/kg；静脉注射)可增加血压(BP)和心率(HR),然而,艾替利氟林不能减轻倾斜引起的血压下降。艾替利氟林也会增加心输出量(CO)[3]。
• 参考文献:

  [1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24.

  [2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5.

  [3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24.

安全

• 海关编码: 2922509090

合成路线

22510-12-9 ~% 709-55-7

文献：Yakugaku Zasshi, , vol. 74, p. 318 Chem.Abstr., , p. 3960

38396-89-3 ~% 709-55-7

文献：Yakugaku Zasshi, , vol. 74, p. 318 Chem.Abstr., , p. 3960

海关

海关编码	2922509090
中文概述	2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%