Etilefrin

Modify Date: 2024-01-19 17:44:05

Etilefrin structure	Common Name	Etilefrin
	CAS Number	709-55-7	Molecular Weight	181.23200
	Density	1.127 g/cm3	Boiling Point	351.7ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₅NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	155.5ºC

Use of Etilefrin

Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist[2]. Etilefrine also is an AMPK activator[1]. Etilefrine can be used for the research of postural hypotension[3].

Name	3-[2-(Ethylamino)-1-hydroxyethyl]phenol
Synonym	More Synonyms

Description	Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist[2]. Etilefrine also is an AMPK activator[1]. Etilefrine can be used for the research of postural hypotension[3].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Target	AMPK
In Vivo	Etilefrine (0.1 mg/kg; i.v.) increases blood pressure (BP) and heart rate (HR), however, Etilefrine does not attenuate the decrease in BP induced by the tilt. Etilefrine also tends to increase cardiac output (CO)[3].
References	[1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24. [2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5. [3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24.

Density	1.127 g/cm3
Boiling Point	351.7ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅NO₂
Molecular Weight	181.23200
Flash Point	155.5ºC
Exact Mass	181.11000
PSA	52.49000
LogP	1.42600
Index of Refraction	1.561

HS Code	2922509090

2-ethylamino-1-...

CAS#:22510-12-9

Etilefrin

CAS#:709-55-7

Literature: Yakugaku Zasshi, , vol. 74, p. 318 Chem.Abstr., , p. 3960

2-Bromo-3'-acet...

CAS#:38396-89-3

Etilefrin

CAS#:709-55-7

Literature: Yakugaku Zasshi, , vol. 74, p. 318 Chem.Abstr., , p. 3960

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

ethylphenylarsine chloride

Aethyl-chlor-phenyl-arsin

Arsine,chloroethylphenyl-(6CI,7CI,8CI)

Arsinous chloride,ethylphenyl

ethylphenylephrine

Aethyl-phenyl-dithiocarbamidsaeure,Ammonium-Salz

ethyl(phenyl)arsinous chloride

Aethylphenylarsinchlorid

Aethylphenylarsenchlorid

ethyl-chloro-phenyl-arsine

ammonium N-ethyl-N-phenyldithiocarbamate

Chloroethylphenylarsine

(RS)-etilefrine

2-ethylamino-1-(3-hydroxy-phenyl)-ethanol

ethyl-phenyl-dithiocarbamic acid,ammonium salt

Aethyl-phenyl-chlor-arsin

[3H]-(+/-)-Etilefrine

Ethylphenylchloroarsine

Etilefrin

Use of Etilefrin

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Etilefrin Biological Activity

Chemical & Physical Properties

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