729607-74-3

• 常用中文名：N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺
• 常用英文名：BMS-707035
• CAS号：729607-74-3
• 分子式：C₁₇H₁₉FN₄O₅S
• 分子量：410.420
• 相关类别： 生物化工 抑制剂 微生物学(Microbiology) Integrase 抑制剂
• 发布时间：2017-06-16 13:29:59
• 更新时间：2026-06-30 10:39:31
• BMS-707035是HIV-1整合酶（IN）抑制剂，IC50为15 nM。

名称

• 中文名: N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺
• 英文名: 2-(1,1-dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxopyrimidine-4-carboxamide
• 中文别名: 抑制剂BMS-707035; 2-(1,1-二氧化物-1,2-硫代吗啉-2-基)-N-(4-氟苄基)-5-羟基-1-甲基-6-氧代-1,6-二氢嘧啶-4-甲酰胺; BMS-707035 5mg试剂; N-[(4-氟苯基)甲基]-1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧代-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺; 2-(1,1-二氧化物-1,2-噻嗪喃-2-基)-N-(4-氟苄基)-5-羟基-1-甲基-6-氧代-1,6-二氢嘧啶-4-甲酰胺; BMS-707035 10mM * 1mL in DMSO试剂; BMS-707035,可逆的HIV-1整合酶(IN)抑制剂
• 英文别名: BMS707035; 2-(4-((4-fluorobenzyl)cbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1l4,2-thiazinane-1,1-bis(olate); BMS 707035;BMS; 4-Pyrimidinecboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin; BMS 707035,HIV-1 intease strand transfer,HIV,Human immunodeficiency virus,antiviral,BMS707035,phamacokinetics,HIV Intease,BMS-707035,CYP,inhibit,strand transfer,Inhibitor; HIV Integrase Inhibitor; BMS-707035, 10 mM in DMSO; 2-(1,1-DIOXOTHIAZINAN-2-YL)-N-[(4-FLUOROPHENYL)METHYL]-5-HYDROXY-1-METHYL-6-OXOPYRIMIDINE-4-CBOXAMIDE; BMS707035 //BP; S1366_Selleck; N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-4-pyrimidinecboxamide; 2-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-cboxamide; UNII-7PR4P7YOKT; 4-Pyrimidinecboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl); 2-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-4-pyrimidinecarboxamide

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₇H₁₉FN₄O₅S
• 分子量: 410.420
• 精确质量: 410.106018
• PSA: 133.47000
• LogP: -2.04
• 外观性状: 粉末
• 折射率: 1.670
• 储存条件: -20℃

生物活性

• 描述: BMS-707035是HIV-1整合酶(IN)抑制剂,IC50为15 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Cotelle P.,3-Hydroxy-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-ones as new HIV-1 integrase inhibitors WO2011046873 A1.,Expert Opin Ther Pat. 2011 Nov;21(11):1799-804.

  [2]. Al-Mawsawi LQ, Al-Safi RI, Neamati N.,Anti-infectives: clinical progress of HIV-1 integrase inhibitors.,Expert Opin Emerg Drugs. 2008 Jun;13(2):213-25.

  [3]. Dayam R, Al-Mawsawi LQ, Neamati N.,HIV-1 integrase inhibitors: an emerging clinical reality.,Drugs R D. 2007;8(3):155-68.

  [4]. Dicker IB, et al. Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors. J Biol Chem. 2007 Oct 26;282(43):31186-96.