161798-02-3

• 常用中文名：非布索坦中间体
• 常用英文名：Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
• CAS号：161798-02-3
• 分子式：C₁₄H₁₂N₂O₃S
• 分子量：288.322
• 发布时间：2018-12-25 12:08:06
• 更新时间：2026-07-17 11:24:01

名称

• 中文名: 2-(3-氰基-4-羟基苯基)-4-甲基-1,3-噻唑-5-羧酸乙酯
• 英文名: Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
• 中文别名: 非布索坦杂质; 非布司他中四A; 非布索坦杂质3(非布司他杂质); 2-(3-氰基-4-羟基苯基)-4-甲基噻唑-5-甲酸乙酯; 非布司他杂质Y; 2-(3-基-4-轻基基)-4-甲基-1,3-曝哗-5-羚酸乙酯; 非布索坦4-羟基乙基酯; 2-(3-氰基-4-羟基苯基)-4-甲基-5-甲酸乙酯噻唑; 非布索坦中间体F4; 非布司他11; 2-(3-氰基-4-羟基)苯基-4-甲基噻唑-5-甲酸乙酯(非布索坦中间体); 2-(3-氰基-4-羟苯基)-4-甲基噻唑-5-羧酸乙酯; 非布司他/非布索坦杂质14; 非布索坦杂质28CAS :161-3; 非布索坦杂质28; 2-(3-氰基-4-羟基苯基)-4-甲基噻唑-5-羧酸酯; 非布司他杂质5; 2-(3-氰基-4-羟基苯基)-4-甲基-1,3-噻唑-5-羧
• 英文别名: Ethyl 2-(3-cyano-4-hydroxyphenyl); FeBuxostat Impurity 28; Febuxostat-3; Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-cboxylate; 2-(3-Cyano-4-hydroxyphenyl)-4-Methyl-1,3-thiazole-5; Ethyl 2-(3-cyano-4-oxocyclohexa-2,5-dien-1-ylidene)-4-methyl-3H-1,3-thiazole-5-cboxylate; ethyl 2-(3-cyano-4-oxocyclohexa-2,5-dien-1-ylidene)-4-methyl-3H-1,3-thiazole-5-carboxylate; Febuxostat Impurity 5; 5-Thiazolecarboxylic acid, 2-(3-cyano-4-hydroxyphenyl)-4-methyl-, ethyl ester; Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-cboxy; Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-cboxylate //BP; Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-5-thiazolecboxylate; Febuxostat Impurity 11/Febuxostat 4-Hydroxy Ethyl Ester/Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-cboxylate; 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-cboxylate; Febuxostat 4-Hydroxy Ethyl Ester; 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-cboxylate; 2-(3-Cyano-4-hydroxyphenyl)-4-Methyl-1,3-thiazole-5-cboxylicacidethylester; ethyl 2-(4-formyl-3-isobutoxyphenyl)-4-methylthiazole-5- cboxylate; ETHYL 2-(3-CYANO-4-HYDROXYPHENYL)-4-METHYLTHIAZOLE-5-CBOXYLATE; ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-cboxylate; 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-5-thiazolecboxylic acid ethyl ester; Febuxostat Impurities4; 5-Thiazolecboxylic acid, 2-(3-cyano-4-hydroxyphenyl)-4-methyl-, ethyl ester

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 475.3±55.0 °C at 760 mmHg
• 分子式: C₁₄H₁₂N₂O₃S
• 分子量: 288.322
• 闪点: 241.3±31.5 °C
• 精确质量: 288.056854
• PSA: 111.19000
• LogP: 4.15
• 外观性状: 粉末
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.629
• 储存条件: 室温，密封，干燥

安全

• 危害码 (欧洲): Xn
• 海关编码: 2934100090

合成路线

25984-63-8 ~% 161798-02-3

文献：WO2012/14117 A1, ;

161797-99-5 ~% 161798-02-3

文献：WO2012/14117 A1, ;

161798-01-2 ~98% 161798-02-3

文献：Vellanki, Siva Rama Prasad; Sahu, Arabinda; Raavi, Satyanarayana; Nuchu, Ravi; Dandala, Ramesh Patent: US2013/303780 A1, 2013 ; Location in patent: Paragraph 0043 ;

934470-15-2 ~% 161798-02-3

文献：EP1932832 A1, ; Page/Page column 16 ; EP 1932832 A1

609-15-4 ~% 161798-02-3

文献：WO2012/14117 A1, ;

上下游产品

上游产品  4
161798-01-2 609-15-4 25984-63-8 161797-99-5
下游产品  1
160844-75-7

海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%