161798-01-2

• 常用中文名：2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯
• 常用英文名：ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
• CAS号：161798-01-2
• 分子式：C₁₄H₁₃NO₄S
• 分子量：291.322
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-12-11 18:06:04
• 更新时间：2026-07-01 19:03:39

名称

• 中文名: 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯
• 英文名: Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
• 中文别名: FEBUXOSTAT 杂质1; 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羟酸乙酯; 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯(非布索坦的中间体); 2-(3-甲酰-4-羟基苯基)-4-甲基噻唑-5-羧酸酯; 2-(3-醛基-4-轻基苯基)-4-甲基嚷-5-羚酸乙酯; 2-(3-甲酰基-4-羟基苯基)-4-甲基噻唑-5- 甲酸乙酯 (F3); 非布司他SM; 非布司他/非布索坦杂质36; 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯(非布司他中间体); 非布司他中间体3; 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯(非布索坦中间体2); 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯(F3); 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯(非布索坦中间体); 2-(3-甲酰基-4-羟基苯基)-4-甲基噻唑-5-甲酸乙酯; 非布索坦杂质Z17(非布司他杂质); (3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯(非布中三); 非布索坦中间体三; 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯噻唑-5-羧酸; 非布司他中间体,2-(3-甲酰基-4-羟基苯基)-4-甲基噻 唑-5-甲酸乙酯; 2-(3-醛基-4-羟苯基)-4-甲基噻唑-5-甲酸乙酯; 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯,非布索坦中间体3; 2-(3-甲酰基-4-羟基苯基)-4-甲基-噻唑-5-羧酸乙酯; 非布索坦杂质Z17; 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯(非布中三); 2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯(非布索坦/非布司他中间体); 非布司他杂质1; 2-(3-醛基-4-羟基苯基)-4-甲基噻吩-5-羧酸乙酯
• 英文别名: ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5; Febuxostat intermediate3; 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-Thiazolecboxylic acid ethyl ester (9CI ACI); Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate; 5-cboxylato-1-ethyl-2-(3-forMyl-4-h; 5-cboxylato-1-ethyl-2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-1H-1; Ethyl 2-(3-formyl-4- hydroxyphenyl)-4; Ethyl 2-(3- aldehyde -4- hydroxyphenyl) -4- methylthiazole -5- cboxylate; cEthyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-cboxylate; Febuxostat Impurity 1; Ethyl 2-(3-formyl-4-hydroxyphenyl); Febuxostat intermediates，Ethyl 2-(3-formyl-4-hydroxyphenyl)-4- methylthiazole-5-cboxylate; Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-cbox; 2- (3-aldehyde 4-hydroxyphenyl) -4-methylthiazole-5-cboxylic acid ethyl ester; Febuxostat Impurity Z17; T5N CSJ BR DQ CVH& DVO2 E1; 2-(3-formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-cboxylate; Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-cboxylate（F3）; ethyl-2-(3-formyl-4-hydroxyphenyl)-4-methyl thiozole-5-cboxylate; Ehtyl 2-(3-Formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-cboxylate; ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazo; Febuxostat PI-2; 2-(3-Formyl-4-hydroxy-phenyl)-4-methyl-thiazole-5-cboxylic acid ethyl ester; ETHYL 2-(3-FORMYL-4-HYDROXYPHENYL)-4-METHYL-1,3-THIAZOLE-5-CBOXYLATE; 5-Thiazolecboxylicacid, 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-, ethyl ester; Ethyl 2-(3-formyl-4-hydroxypheip)-4-methylthiazole-5-cboxylate; Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate; l^{4},3-thiazol-1-yl; Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate; 5-Thiazolecboxylic acid, 2-(3-formyl-4-hydroxyphenyl)-4-methyl-, ethyl ester (9CI, ACI); 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-cboxylate; 4-hydroxyphenyL; Thiazolecboxylicacid,2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-,ethylester; 5-Thiazolecarboxylic acid, 2-(3-formyl-4-hydroxyphenyl)-4-methyl-, ethyl ester; 2-(3-formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-cboxylat; Febuxostat Impurities1; Febuxostat-23; 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-5-Thiazolecboxylicacid ethyl ester; Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-cboxylate 2; ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-cboxylate; Febuxostat Inter. (avoid the patent); Ethyl 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-5-Thiazolecboxylate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 446.6±55.0 °C at 760 mmHg
• 熔点: 116 °C
• 分子式: C₁₄H₁₃NO₄S
• 分子量: 291.322
• 闪点: 223.9±31.5 °C
• 精确质量: 291.056519
• PSA: 104.73000
• LogP: 4.25
• 外观性状: 固体;Light orange to Yellow to Green powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.625
• 储存条件: 2-8°C，惰性气体氛围

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934100090

合成路线

161797-99-5 100-97-0 ~72% 161798-01-2

文献：RANBAXY LABORATORIES LIMITED; CHATTERJEE, Pranab; NATH, Asok; SOKHI, Sarbjot Singh; PRASAD, Mohan Patent: WO2012/14117 A1, 2012 ; Location in patent: Page/Page column 12 ;

609-15-4 ~% 161798-01-2

文献：WO2012/14117 A1, ;

25984-63-8 ~% 161798-01-2

文献：WO2012/14117 A1, ;

上下游产品

上游产品  4
161797-99-5 100-97-0 609-15-4 25984-63-8
下游产品  3
160844-75-7 161798-03-4 161798-02-3

海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%