1837-57-6

• 常用中文名：乳酸依沙吖啶
• 常用英文名：Ethacridine lactate
• CAS号：1837-57-6
• 分子式：C₁₈H₂₁N₃O₄
• 分子量：343.377
• 相关类别： 原料药 人工合成抗感染类药 消毒防腐药
• 发布时间：2018-07-04 13:46:42
• 更新时间：2024-01-05 09:45:03
• Ethacridine lactate 是一种聚 (ADP-核糖) 糖基水解酶 (PARG) 抑制剂。

名称

• 中文名: 乳酸依沙吖啶
• 英文名: 6,9-diamino-2-ethoxyacridine lactate
• 中文别名: 2-乙氧基-6,9-二氨基吖啶乳酸盐; 雷佛奴尔; 乳酸依沙吖啶(一水物); 6,9-二胺-2-乙氧吖啶; 雷凡醇; 利凡诺
• 英文别名: Ethacridine Lactate; RIVANOL; rivinol; 2-Hydroxypropanoic acid - 7-ethoxy-3,9-acridinediamine (1:1); 7-ethoxy-acridine-3,9-diyldiamine,DL lactate; rimaon; MFCD00013149; 2-ethoxy-6,9-diaminoacridine lactate; UNII:7T7T2I9823; Propanoic acid, 2-hydroxy-, compd. with 7-ethoxy-3,9-acridinediamine (1:1); flavitrol; EINECS 217-408-1; ETHODIN; TCMDC-123983; ACRYNOL; metifex; 2-Hydroxypropanoic acid - 7-ethoxyacridine-3,9-diamine (1:1); Vucine; ACRINOL; Ethacridine (lactate)

物化性质

• 沸点: 270 °C(lit.)
• 熔点: 62-67 °C(lit.)
• 分子式: C₁₈H₂₁N₃O₄
• 分子量: 343.377
• 闪点: 143 °C
• 精确质量: 343.153198
• PSA: 131.69000
• LogP: 3.56530
• 蒸汽压: 4.72E-11mmHg at 25°C
• 储存条件:

  保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物

• 水溶解性: soluble
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:4

  3.氢键受体数量:7

  4.可旋转化学键数量:3

  5.互变异构体数量:22

  6.拓扑分子极性表面积132

  7.重原子数量:25

  8.表面电荷:0

  9.复杂度:371

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：粉末

  2. 密度（g/mL,25ºC）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）： 未确定

  4. 熔点（ºC）：245

  5. 沸点（ºC）：未确定

  6. 沸点（ºC，0.4mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（°C）：未确定

  9. 比旋光度（ºC）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,109ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：能溶解于水的

生物活性

• 描述: Ethacridine lactate 是一种聚 (ADP-核糖) 糖基水解酶 (PARG) 抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 靶点:

  PARG[1]

• 体外研究: Ethacridine lactate对大多数革兰氏阳性菌如链球菌和葡萄球菌有效,对革兰氏阴性菌(P seudomonas aeruginosa)无效[1]。 Ethacridine Lactate是一种安全的堕胎药,成功率约为80％,几乎没有任何副作用[2]。
• 体内研究: 胎盘滞留的发生率为16％。羊膜外注射是一种技术上简单的手术,甚至可以在怀孕13-15周之间进行羊膜腔内注射困难。其杀菌特性可最大限度地降低后遗症感染的危险。它可用于某些医学病症,如高血压,支气管哮喘,其中高渗盐水和前列腺素是禁忌的[2]。 Ethacridine lactate比其他滴注流产方法表现更好,是一种安全有效的方法。 Ethacridine lactate在92.8％的病例中诱导成功流产,远高于文献中发现的(约82％)。其他4例因流卧胎,宫颈难产和子宫惯性[2]而发生流产失败。
• 参考文献:

  [1]. Rotin LE, et al. Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. 2016 Nov;101(11):e449-e453.

  [2]. Purandare VN, et al. The place of ethacridine lactate for mid-trimester M.T.P. (Multicentric study). J Postgrad Med. 1977 Apr;23(2):77-83.

  [3]. Gupta S, et al. Ethacridine lactate -- a safe and effective drug for termination of pregnancy. Indian J Matern Child Health. 1993;4(2):59-61.

MSDS

Name: 6 9-Diamino-2-Ethoxyacridine Lactate 95% (Titr.) Material Safety Data Sheet Synonym: 6,9-Acridinediamine, 2-Ethoxy-, 2-Hydroxypropanote; Acrinol; Ethodin CAS: 1837-57-6 Section 1 - Chemical Product MSDS Name:6 9-Diamino-2-Ethoxyacridine Lactate 95% (Titr.) Material Safety Data Sheet Synonym:6,9-Acridinediamine, 2-Ethoxy-, 2-Hydroxypropanote; Acrinol; Ethodin Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 1837-57-6 Propanoic acid, 2-hydroxy-, compd. wit 95 217-408-1 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. The toxicological properties of this material have not been fully investigated. Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 1837-57-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: yellow Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: N/A Explosion Limits, upper: N/A Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C18H21N3O4.H2O Molecular Weight: 361.39 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 1837-57-6: OD4725000 LD50/LC50: Not available. Carcinogenicity: Propanoic acid, 2-hydroxy-, compd. with7-ethoxy-3,9-acridine - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 1837-57-6: No information available. Canada CAS# 1837-57-6 is listed on Canada's NDSL List. CAS# 1837-57-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 1837-57-6 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、急性毒性：小鼠经皮下LD50：120mg/kg；兔子经皮下LD50：100mg/kg；兔子经静脉LDLo：20mg/kg； 2、其他多剂量毒性：大鼠经口TDLo：48mg/kg/30D-C；小鼠经腹腔TDLo：420mg/kg/21D-I； 3、 致突变性 微生物鼠伤寒沙门氏菌突变测试系统：16μg/plate； 大肠埃希氏菌DNA加和测试系统：5μmol/L； 枯草芽孢杆菌DNA修复测试系统：1mg/L； 微生物突变测试系统：250mg/L。 生态学数据: 对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境 CHEMICAL IDENTIFICATION RTECS NUMBER : OD4725000 CAS REGISTRY NUMBER : 1837-57-6 LAST UPDATED : 199806 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C15-H15-N3-O.C3-H6-O3 MOLECULAR WEIGHT : 343.42 WISWESSER LINE NOTATION : T C666 BNJ EZ IZ LO2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Vascular - shock TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 48 gm/kg/30D-C TOXIC EFFECTS : Endocrine - other changes Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 420 mg/kg/21D-I TOXIC EFFECTS : Liver - changes in liver weight Endocrine - changes in spleen weight MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 250 mg/L REFERENCE : PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 56,500,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5763 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 23 (estimated)

安全

• 危害码 (欧洲): Xi,Xn
• 风险声明 (欧洲): R36/37/38:Irritating to eyes, respiratory system and skin . R22:Harmful if swallowed. R40:Limited evidence of a carcinogenic effect. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
• 安全声明 (欧洲): S26-S24/25-S37/39
• WGK德国: 3
• RTECS号: UT6410000
• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%