862574-88-7

• 常用中文名：1-(2,2-二氟苯并[D][1,3]二氧杂环戊烯-5-基)环丙烷甲酸
• 常用英文名：1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid
• CAS号：862574-88-7
• 分子式：C₁₁H₈F₂O₄
• 分子量：242.176
• 发布时间：2018-12-04 17:14:59
• 更新时间：2026-07-22 22:07:26

名称

• 中文名: 1-(2,2-二氟-苯并[1,3]二氧代l-5-基)-环丙烷羧酸
• 英文名: 1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid
• 中文别名: VX809中间体; LUMACATOR中间体; K1202 1-(2,2-二氟苯并[D][1,3]二氧杂环戊烯-5-基)环丙烷甲酸; 鲁马卡托; 1-(2,2-二氟苯并[D][1,3]二氧戊环-5-基)环丙甲酸; 1-(2,2-二氟苯并二氧杂环戊烯-5-基)环丙烷羧酸; 1-(2,2-二氟-苯并[1,3]二恶茂-5-基)环丙甲酸; 1-(2,2-二氟苯并[D][1,3]二羟基-5-基)环丙烷-1-甲酸; 2,2-二氟胡椒环环丙烷甲酸; 1-(2,2-二氟-苯并[1,3]二氧代L-5-基)-环丙烷羧酸; 1H-吲唑-25-醇; 1-(2,2-二氟苯并[D][1,3]1,3-二氧杂环戊烯-5-基)环丙基甲酸; 1-(2,2-二氟-2H-1,3-苯并二恶唑-5-基)环丙烷-1-羧酸; 二氟苯并[D][1,3]二氧杂环戊烯-5-基)环丙烷甲酸
• 英文别名: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecboxylic; Lumacator intermediate; 1-(2,2 difluro-l,3 benzodioxolo-5-yl) cycloprapane cboxylic acid; 1-(2,2-Difluorobenzodioxol-5-yl)cyclopropanecboxylic acid; 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid; 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid; 1-(2,2-Difluorobenzo[1,3]dioxol-5-yl); Cyclopropanecboxylic acid, 1-(2,2-difluoro-1,3-benzodioxol-5-yl); 1-(2,2-DifL; 1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-cboxylic acid; 1-(2,2-Difluoro Benzene Bing[d][1,3]DioxygenPentracyclic-5-base)Cyclopropionic acid; uorobenzo[1,3]dioxoL; 1-(2,2-Difluoro-benzo[1,3]diaxol-5-yl)-cyclopropanecboxylicacid; 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-cboxylicacid; 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-cboxyl; 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarboxylic acid; 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecboxyli; EOS-61000; 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecboxylic acid; 1-(2,2-Difluoro-1,3-benzodioxol-5-yl) cyclopropanecboxylicacid; 1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropan-cboxylic acid; 1-(2,2-Difluorobenzo[1,3]Dioxol-5-Yl)Cyclopropane-1-Cboxylic Acid; 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropan; 1-(2,2-Difluorobenzene Dioxypentocyclo-5-yl)cyclopropylic acid; 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecboxylic acid1-(2,2; 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-cboxylic Acid; 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecboxylicacid; 1-(2,2-difluoro-1,3-dioxaindan-5-yl)cyclopropane-1-cboxylic acid

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 331.1±42.0 °C at 760 mmHg
• 分子式: C₁₁H₈F₂O₄
• 分子量: 242.176
• 闪点: 154.0±27.9 °C
• 精确质量: 242.039063
• PSA: 55.76000
• LogP: 2.65
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.588
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi
• 海关编码: 2932999099

合成路线

862574-87-6 ~80% 862574-88-7

文献：VERTEX PHARMACEUTICALS INCORPORATED; ALARGOVA, Rossitza Gueorguieva; DUNBAR, Craig Antony; KADIYALA, Irina Nikolaevna Patent: WO2014/14841 A1, 2014 ; Location in patent: Paragraph 00314 - 00317 ;

1634-04-4 101-83-7 ~% 862574-88-7

文献：US2011/98311 A1, ;

862574-87-6 96042-30-7 ~% 862574-88-7

文献：US2012/46330 A1, ; US 20120046330 A1

33070-32-5 ~% 862574-88-7

文献：WO2011/119984 A1, ; WO 2011/119984 A1

656-46-2 ~% 862574-88-7

文献：WO2011/119984 A1, ; WO 2011/119984 A1

72768-97-9 ~% 862574-88-7

文献：WO2011/119984 A1, ; WO 2011/119984 A1

476473-97-9 ~% 862574-88-7

文献：WO2011/119984 A1, ; WO 2011/119984 A1

1335233-51-6 ~% 862574-88-7

文献：WO2011/119984 A1, ; WO 2011/119984 A1

上下游产品

上游产品  8
862574-87-6 1634-04-4 101-83-7 96042-30-7
33070-32-5 656-46-2 72768-97-9 476473-97-9
下游产品  2
1160221-26-0 1152311-62-0

海关

海关编码	2932999099
中文概述	2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%