1152311-62-0

• 常用中文名：替扎卡托
• 常用英文名：Tezacaftor(VX-661)
• CAS号：1152311-62-0
• 分子式：C₂₆H₂₇F₃N₂O₆
• 分子量：520.498
• 相关类别： 生物化工 抑制剂 跨膜转运体(Transmembrane Transporters) CFTR 调节剂
• 发布时间：2018-07-03 11:21:22
• 更新时间：2026-06-30 22:20:47
• VX-661 是 F508del CFTR 的矫正器,能够帮助 CFTR 蛋白与细胞表面结合。

名称

• 中文名: 替扎卡托
• 英文名: 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide
• 中文别名: VX-661/VX6611-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺; VX-661/帕夫骨化醇; 1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺; (R)-1-(2,2-二氟苯并[D][1,3]二噁茂-5-基)-N-[1-(2,3-二羟基丙基)-6-氟-2-(1-羟基-2-甲基-2-丙基)-5-吲哚基]环丙烷甲酰胺; 特萨卡托; 1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙; VX-661; 弗罗曲坦杂质7
• 英文别名: Tezacaftor, 10 mM in DMSO; tezacaftorum; tezacaftor(VX661); 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecboxamide; VX-661 //BP; N,3,3-Trimethyl-1,5-dioxaspiroundecan-9-amine Hydrochloride (4-Methylaminocyclohexanone 2',2'-Dimethyltrimethylene Ketal Hydrochloride); (r)-1-(2,2-difluorobenzo[d] [1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide; VX-661/VX661; cs-1078; 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-cboxamide; (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy; VX 661;VX661;VX-661; TEZACAFTOR; (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-[1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methyl-2-propyl)-5-indolyl]cyclopropanecboxamide; 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecboxamide VX661; Cyclopropanecboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]; VX661/Tezacaftor; Tezacaftor D4Q: What is Tezacaftor D4 Q: What is the CAS Number of Tezacaftor D4; VX 661; VX661;VX-661; vx661; 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-{1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methyl-2-propanyl)-1H-indol-5-yl}cyclopropanecarboxamide; (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-Methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecboxaMide; inhibit,Tezacaftor,Inhibitor,VX-661,Cystic fibrosis transmembrane conductance regulator,Autophagy,VX 661,CFTR; Tezacaftor

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 610.8±55.0 °C at 760 mmHg
• 分子式: C₂₆H₂₇F₃N₂O₆
• 分子量: 520.498
• 闪点: 323.2±31.5 °C
• 精确质量: 520.182129
• PSA: 113.18000
• LogP: 2.65
• 外观性状: 粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.628
• 储存条件: -20℃

生物活性

• 描述: VX-661 是 F508del CFTR 的矫正器,能够帮助 CFTR 蛋白与细胞表面结合。
• 相关类别:
  信号通路 >> 跨膜转运 >> CFTR
  研究领域 >> 癌症
• 体外研究: 在体外,与单独的VX-661相比,VX-661和ivacaftor的组合导致更高的CFTR活性[2]。
• 参考文献:

  [1]. Treatment with VX-661 and Ivacaftor in a Phase 2 Study Resulted in Statistically Significant Improvements in Lung Function in People with Cystic Fibrosis Who Have Two Copies of the F508del Mutation. April 18, 2013

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