79103-90-5

• 常用中文名：瓜子金皂苷XXXI
• 常用英文名：Polygalasaponin XXXI
• CAS号：79103-90-5
• 分子式：C₇₅H₁₁₂O₃₆
• 分子量：1589.670
• 相关类别： 信号通路 抗感染 流感病毒
• 发布时间：2018-03-14 08:00:00
• 更新时间：2026-06-30 18:54:18
• Polygalasaponin XXXI (Onjisaponin F) 是鼻内注射流感 HA 疫苗的有效佐剂,可保护流感病毒感染

名称

• 中文名: 瓜子金皂苷XXXI
• 英文名: onjisaponin F
• 中文别名: 瓜子金皂苷XXXI(对照品); 远志皂苷 F; (2S,3R,4S,4,6,6BR,8AS,12AS,14,14BR)-8A-((((2S,3R,4S,5R,6R)-3-(((2S,3R,4S,5S,6S)-5-(((2S,3R,4S,5R)-3,5-二羟基-4-(((2S,3R,4S,5S)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)-4-(((2S,3R,4R)-3,4-二羟基-4-(羟甲基)四氢呋喃-2-基)氧基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-4-羟基-6-甲基-5-(((E)-3-(3,4,5-三甲氧基苯基)丙烯酰基)氧基)四氢-2H-吡喃-2-基)氧基)羰; Polygalasaponin XXXI #天然产物 HY-N2216; 远志皂苷F瓜子金皂苷XXXI; 对照品/瓜子金皂苷XXXI; 瓜子金皂苷XXXI标准品; ONJISAPONIN F游离
• 英文别名: Onjisaponin F Polygalasaponin XXXI; Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, 28-[O-D-apio-β-D-furanosyl-(1→3)-O-[O-α-L-abinopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)]-O-6-deoxy-α-L-mannopyranosyl-(1→2)-6-deoxy-4-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-β-D-galactopyranosyl] ester, (2β,3β; Onjisaponin F; (2S,3R,4S,4,6,6bR,8aS,12aS,14,14bR)-8a-((((2S,3R,4S,5R,6R)-3-(((2S,3R,4S,5S,6S)-5-(((2S,3R,4S,5R)-3,5-Dihydroxy-4-(((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4-(((2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyl-5-(((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)oxy)tetrahydro-2H-pyran-2-yl)oxy)carbonyl)-2-hydroxy-6b-(hydroxymethyl)-4,6a,11,11,14b-pentamethyl-3-(((2R; α-L-Arabinopyranosyl-(1->3)-α-D-xylopyranosyl-(1->4)-6-deoxy-3-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-α-L-mannopyranosyl-(1->2)-6-deoxy-1-O-[(2β,3β)-3-(be ta-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-β-D-galactopyranose; Polygalasaponin XXX

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₇₅H₁₁₂O₃₆
• 分子量: 1589.670
• 精确质量: 1588.693359
• PSA: 542.80000
• LogP: 4.95
• 折射率: 1.651
• 储存条件: 2-8°C，保存于惰性气体中

生物活性

• 描述: Polygalasaponin XXXI (Onjisaponin F) 是鼻内注射流感 HA 疫苗的有效佐剂,可保护流感病毒感染
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 体外研究: polyglasaponinxxxi(Onjisaponin F)在鼻腔冲洗液中也能提高抗HA-IgA和IgG-Ab滴度,而Onjisaponin E和Onjisaponin E仅显著提高抗HA-IgA抗体滴度。多聚糖脂蛋白XXXI可诱导对流感病毒鼻腔感染的保护性免疫[1]。远志皂苷XXXI(Onjisaponin F)(1或10µg/mL)也诱导大鼠基底前脑细胞中ChAT mRNA水平[2]。
• 体内研究: 鼻内接种多聚糖脂蛋白XXXI(Onjisaponin F)抑制小鼠适应型流感病毒A/PR/8/34在感染小鼠支气管肺泡灌洗液中的增殖[1]。
• 参考文献:

  [1]. T Nagai, et al. Onjisaponins, From the Root of Polygala Tenuifolia Willdenow, as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34.

  [2]. T Yabe, et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia, Constituents of Kampo (Japanese Herbal) Medicine, Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14.