瓜子金皂苷XXXI

• 常用名: 瓜子金皂苷XXXI
• 英文名: Polygalasaponin XXXI
• CAS号: 79103-90-5
• 分子量: 1589.670
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₇₅H₁₁₂O₃₆
• 熔点: N/A
• 闪点: N/A

瓜子金皂苷XXXI用途

Polygalasaponin XXXI (Onjisaponin F) 是鼻内注射流感 HA 疫苗的有效佐剂,可保护流感病毒感染

瓜子金皂苷XXXI名称

• 中文名: 瓜子金皂苷XXXI
• 英文名: onjisaponin F

瓜子金皂苷XXXI生物活性

• 描述: Polygalasaponin XXXI (Onjisaponin F) 是鼻内注射流感 HA 疫苗的有效佐剂,可保护流感病毒感染
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
• 体外研究: polyglasaponinxxxi(Onjisaponin F)在鼻腔冲洗液中也能提高抗HA-IgA和IgG-Ab滴度,而Onjisaponin E和Onjisaponin E仅显著提高抗HA-IgA抗体滴度。多聚糖脂蛋白XXXI可诱导对流感病毒鼻腔感染的保护性免疫[1]。远志皂苷XXXI(Onjisaponin F)(1或10µg/mL)也诱导大鼠基底前脑细胞中ChAT mRNA水平[2]。
• 体内研究: 鼻内接种多聚糖脂蛋白XXXI(Onjisaponin F)抑制小鼠适应型流感病毒A/PR/8/34在感染小鼠支气管肺泡灌洗液中的增殖[1]。
• 参考文献:

  [1]. T Nagai, et al. Onjisaponins, From the Root of Polygala Tenuifolia Willdenow, as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34.

  [2]. T Yabe, et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia, Constituents of Kampo (Japanese Herbal) Medicine, Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14.

瓜子金皂苷XXXI物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₇₅H₁₁₂O₃₆
• 分子量: 1589.670
• 精确质量: 1588.693359
• PSA: 542.80000
• LogP: 4.95
• 折射率: 1.651
• 储存条件: 2-8°C，保存于惰性气体中

瓜子金皂苷XXXI英文别名

• Polygalasaponin XXXI
• β-D-Galactopyranose, O-α-L-arabinopyranosyl-(1->3)-O-α-D-xylopyranosyl-(1->4)-O-6-deoxy-3-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-α-L-mannopyranosyl-(1->2)-6 -deoxy-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-
• α-L-Arabinopyranosyl-(1->3)-α-D-xylopyranosyl-(1->4)-6-deoxy-3-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-α-L-mannopyranosyl-(1->2)-6-deoxy-1-O-[(2β,3β)-3-(be ta-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-β-D-galactopyranose