915363-56-3

• 常用中文名：8-氯-4-[(3-氯-4-氟苯基)氨基]-6-[[[1-(1-乙基-4-哌啶)-1H-1,2,3-三唑-4-基]甲基]氨基]-3-喹啉甲腈
• 常用英文名：Cot inhibitor-2
• CAS号：915363-56-3
• 分子式：C₂₆H₂₅Cl₂FN₈
• 分子量：539.43500
• 相关类别： 有机原料 有机氟化合物 氟苯腈系列
• 发布时间：2018-12-13 17:54:55
• 更新时间：2026-07-01 17:47:08
• Cot 抑制剂-2是COT/Tpl2抑制剂。

名称

• 中文名: 8-氯-4-[(3-氯-4-氟苯基)氨基]-6-[[[1-(1-乙基哌啶-4-基)-1H-1,2,3-三唑-4-基]甲基]氨基]喹啉-3-甲腈
• 英文名: 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-carbonitrile
• 中文别名: COT抑制剂2; COT/TPL2抑制剂(COT INHIBITOR-2); COT抑制剂2,10 MM DMSO 溶液
• 英文别名: 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1; 3-Quinolinecbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]Methyl]amino]; substituted 6-aminoquinoline-3-carbonitrile,34; 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl]amino]quinoline-3-carbonitrile; Tpl2-IN-34 (Tpl2 inhibitor 34; 8-CHLORO-4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[[[1-(1-ETHYLPIPERIDIN-4-YL)-1H-1,2,3-TRIAZOL-4-YL]METHYL]AMINO]QUINOLINE-3-CARBONITRILE; COT INHIBITOR2; COT INHIBITOR 2; Cot inhibitor-2, 10 mM in DMSO; Tpl2-IN-34; 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecbonitrile; MAP3K8-IN-34)

物化性质

• 密度: 1.45
• 沸点: 713.3ºC at 760 mmHg
• 分子式: C₂₆H₂₅Cl₂FN₈
• 分子量: 539.43500
• 闪点: 385.2ºC
• 精确质量: 538.15600
• PSA: 94.69000
• LogP: 6.24028
• 折射率: 1.702
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Cot 抑制剂-2是COT/Tpl2抑制剂。
• 相关类别:
  信号通路 >> 细胞凋亡 >> TNF受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Wu, Junjun et al Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-production in human whole blood. Bioorganic & Medicinal Chemistry Letters (2009), 19(13), 3485-3488.

合成路线

915364-18-0 1175146-85-6 ~% 915363-56-3

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 13 p. 3485 - 3488

915364-18-0 1175146-85-6 ~% 915363-56-3

文献：Wu, Junjun; Green, Neal; Hotchandani, Rajeev; Hu, Yonghan; Condon, Jeffrey; Huang, Adrian; Kaila, Neelu; Li, Huan-Qiu; Guler, Satenig; Li, Wei; Tam, Steve Y.; Wang, Qin; Pelker, Jeffrey; Marusic, Suzana; Hsu, Sang; Perry Hall; Telliez, Jean-Baptiste; Cui, Junqing; Lin, Lih-Ling Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 13 p. 3485 - 3488

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