1665-56-1

• 常用中文名：脱水差向四环素
• 常用英文名：Anhydrotetracyclin
• CAS号：1665-56-1
• 分子式：C₂₂H₂₂N₂O₇
• 分子量：426.41900
• 相关类别： 研究领域 感染
• 发布时间：2018-03-28 08:00:00
• 更新时间：2026-07-27 13:54:21
• 无水四环素在体外显示出剂量依赖性和对四环素降解酶的有效抑制[1]。

名称

• 中文名: 脱水差向四环素
• 英文名: (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide
• 中文别名: 莱姆霉素杂质C; 四环素杂质C; 金霉素杂质10(金霉素杂质J); 脱水四环素
• 英文别名: Chlortetracycline Impurity 10 (Chlortetracycline Impurity J); (4S)-Anhydrotetracycline; AnhydrotetracyclineSee A656050; 2-Naphthacenecboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, (4S,4aS,12aS); (4S)-4β-Dimethylamino-1,4,4aβ,5,12,12a-hexahydro-3,10,11,12aβ-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecboxamide; (1S)-1α-(Dimethylamino)-2,4aα,6,7-tetrahydroxy-4,5-dioxo-11-methyl-1,4a,12,12aα-tetrahydronaphthacene-3-cboxamide; 5a,6-Anhydrotetracycline; AnhydrotetracyclineQ: What is Anhydrotetracycline Q: What is the CAS Number of Anhydrotetracycline Q: What is the storage condition of Anhydrotetracycline Q: What e the applications of Anhydrotetracycline; Tetracycline Impurity C (Chlortetracycline Impurity J, Lymecycline Impurity C, Anhydrotetracycline); (2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione; (4R)-4α-Dimethylamino-1,4,4aβ,5,12,12a-hexahydro-3,10,11,12aβ-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecboxamide; Tetracycline Impurity C; 2-Naphthacenecboxamide, 1,4,4A,5,12,12A-hexahydro-4-(dimethylamino)-1,12-dioxo-6-methyl-3,10,11,12A-tetrahydroxy-, (4S-(4-alpha,4A-alpha,12A-alpha)); Lymecycline Impurity C; 5a,6-anhydrotetracycline; 4-ianhydrotetracycline; 4-i-Anhydrotetracycline; 3,10,11,12aβ-Tetrahydroxy-4β-(dimethylamino)-6-methyl-1,12-dioxo-1,4,4aβ,5,12,12a-hexahydronaphthacene-2-cboxamide

物化性质

• 密度: 1.6 g/cm3
• 沸点: 618.6ºC at 760 mmHg
• 分子式: C₂₂H₂₂N₂O₇
• 分子量: 426.41900
• 闪点: 327.9ºC
• 精确质量: 426.14300
• PSA: 161.39000
• LogP: 1.15610
• 蒸汽压: 3.66E-16mmHg at 25°C
• 折射率: 1.76
• 储存条件: 室温

生物活性

• 描述: 无水四环素在体外显示出剂量依赖性和对四环素降解酶的有效抑制[1]。
• 相关类别:
  研究领域 >> 感染
• 靶点:

  Tetracycline inactivating enzyme[1]

• 体外研究: 体外实验表明,无水四环素(0.1μM-10 mM)对四环素破坏酶具有剂量依赖性和强抑制作用[1]。
• 参考文献:

  [1]. Markley JL, et al. Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. ACS Infect Dis. 2019 Apr 12;5(4):618-633.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QI9277520 CHEMICAL NAME : 2-Naphthacenecarboxamide, 1,4,4a,5,12,12a-hexahydro-4-(dimethylamino)-1,12-diox o-6-methyl- 3,10,11,12a-tetrahydroxy-, (4S-(4-alpha,4a-alpha,12a-alpha))- CAS REGISTRY NUMBER : 1665-56-1 LAST UPDATED : 199009 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C22-H22-N2-O7 MOLECULAR WEIGHT : 426.46 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 134 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 34 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 20 mg/L REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,403,1974

安全

• 危害码 (欧洲): T

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