1228105-51-8

• 常用中文名：SMCC-DM1
• 常用英文名：dm1-smcc
• CAS号：1228105-51-8
• 分子式：C₅₁H₆₆ClN₅O₁₆S
• 分子量：1072.612
• 相关类别： 信号通路 抗体- 药物偶联物 Drug-Linker Conjugates for ADC
• 发布时间：2018-04-05 08:01:56
• 更新时间：2026-07-11 22:25:15
• SMCC-DM1是由连接桥SMCC和DM1连接而成的,用来制备抗体偶联药物。DM1 (mertansine),是含硫醇的美登木素生物碱,是一种有效的微管破坏剂。

名称

• 中文名: SMCC-DM1
• 英文名: SMCC-DM1
• 中文别名: 2,5-二氧代吡咯烷-1-基 4-((3-((3-(((S)-1-(((14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-氯-14-羟基-85,14-二甲氧基-33,2,7,10-四甲基-12,6-二氧代-7-氮杂-1(6,4)-恶嗪烷-3(2,3)-环氧乙烷-8(1,3)-苯环十四烷-10,12-二烯-4-基)氧基)-1-氧代丙-2-基)(甲基)氨基)-3-氧代丙基)硫基)-2,5-二氧代吡咯烷-1-基)甲基)环己烷-1-甲酸酯; N2'-脱乙酰基-N2'-[3-[[1-[[4-[[(2,5-二氧代-1-吡咯烷基)氧基]羰基]环己基]甲基]-2,5-二氧代-3-吡咯烷基]硫代]-1-氧丙基]-美登素; DM1-SMCC试剂
• 英文别名: SMCC-MDC; 2,5-Dioxopyrrolidin-1-yl 4-((3-((3-(((S)-1-(((14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl)oxy)-1-oxopropan-2-yl)(methyl)amino)-3-oxopropyl)thio)-2,5-dioxopyrrolidin-1-yl)methyl)cyclohexane-1-cboxylate; SMCC-DM1 (DM1-SMCC); Phenol,4-chloro-4-iodo; DMI-SMCC; DM1 SMCC; DM1SMCC; SMCC-DM1, 10 mM in DMSO; N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine; DM1-SMCC; DM1-SMC; 2,5-Dioxopyrrolidin-1-yl 4-((3-((3-(((2S)-1-(((14S,16S,33S,2R,4R,10E,12Z,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl)oxy)-1-oxopropan-2-yl)(methyl)amino)-3-oxopropyl)thio)-2,5-dioxopyrrolidin-1-yl)methyl)cyclohexane-1-cboxylate; DMA-SMCC; High quality 1228-8 DM1-SMCC; 2,5-dioxopyrrolidin-1-yl 4-({3-[(2-{[(2S)-1-{[(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11,1.03,]hexacosa-10,11,13,16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)cbamoyl}ethyl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}methyl)cyclohexane-1-cboxylate; N2'-Deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine; Maytansine, N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₅₁H₆₆ClN₅O₁₆S
• 分子量: 1072.612
• 精确质量: 1071.391357
• PSA: 282.83000
• LogP: 3.28
• 折射率: 1.626
• 储存条件: 2-8℃

生物活性

• 描述: SMCC-DM1是由连接桥SMCC和DM1连接而成的,用来制备抗体偶联药物。DM1 (mertansine),是含硫醇的美登木素生物碱,是一种有效的微管破坏剂。
• 相关类别:
  信号通路 >> 抗体- 药物偶联物 >> Drug-Linker Conjugates for ADC
  研究领域 >> 癌症