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12771-72-1生产厂家

12771-72-1价格

12771-72-1

12771-72-1结构式
12771-72-1结构式
  • 常用中文名:震颤真菌毒素
  • 常用英文名:Verruculogen
  • CAS号:12771-72-1
  • 分子式:C20H24BrN3O4
  • 分子量:511.567
  • 相关类别: 分析化学 标准品 食品和化妆品标准品
  • 发布时间:2018-07-14 18:23:05
  • 更新时间:2024-01-03 02:05:20
  • Verruculogen 是一种主要由青霉和曲霉属产生的毒素,在受感染的动物中引起严重震颤。Verruculogen 抑制 Ca2+ 激活的 K+ 通道。Verruculogen 是哺乳动物细胞周期的 M 期抑制剂。

化源商城直购

中文名 疣孢青霉原
英文名 verruculogen
中文别名 震颤真菌毒素
英文别名 Verruculogen
VERRUCULOGEN FROM PENICILLIUM VERRUCULOS
VERRUCOLOGEN
tr1
Verruculogenresearch grade
(5R,10S,10aR,14aS,15bS)-10,10a-Dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methylprop-1-en-1-yl)-1,10,10a,14,14a,15b-hexahydro-12H-3,4-dioxa-5a,11a,15a-triazacycloocta[1,2,3-lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione
5H,12H-3,4-Dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione, 1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propen-1-yl)-, (5R,10S,10aR,14aS,15bS)-
3h)-dione,1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimeth
(5R,10S,10aR,14aS,15bS)-10,10a-Dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propen-1-yl)-1,10,10a,14,14a,15b-hexahydro-12H-3,4-dioxa-5a,11a,15a-triazacycloocta[1,2,3-lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione
TR-1TOXIN
密度 1.5±0.1 g/cm3
沸点 738.4±60.0 °C at 760 mmHg
熔点 233ºC
分子式 C20H24BrN3O4
分子量 511.567
闪点 400.3±32.9 °C
精确质量 511.231842
PSA 112.01000
LogP 2.60
外观性状 白色粉末
蒸汽压 0.0±2.6 mmHg at 25°C
折射率 1.691
储存条件 2-8°C
分子结构

1、 摩尔折射率:133.50

2、 摩尔体积(m3/mol):360.5

3、 等张比容(90.2K):1042.6

4、 表面张力(dyne/cm):69.9

5、 极化率(10-24cm3):52.92

计算化学

1、 疏水参数计算参考值(XlogP):1.8

2、 氢键供体数量:2

3、 氢键受体数量:7

4、 可旋转化学键数量:2

5、 拓扑分子极性表面积(TPSA):114

6、 重原子数量:37

7、 表面电荷:0

8、 复杂度:999

9、 同位素原子数量:0

10、 确定原子立构中心数量: 0

11、 不确定原子立构中心数量:5

12、 确定化学键立构中心数量:0

13、 不确定化学键立构中心数量:0

14、 共价键单元数量:1

更多

1. 性状:未确定

2. 密度(g/mL, 25 ℃ ):未确定

3. 相对蒸汽密度(g/mL,空气=1):未确定

4. 熔点(ºC):未确定

5. 沸点(ºC,常压):未确定

6. 沸点(ºC,0.05mmHg):未确定

7. 折射率:未确定

8. 闪点(ºC):未确定

9. 比旋光度(º):未确定

10. 自燃点或引燃温度(ºC):未确定

11. 蒸气压(20ºC):未确定

12. 饱和蒸气压(kPa,60ºC):未确定

13. 燃烧热(KJ/mol):未确定

14. 临界温度(ºC):未确定

15. 临界压力(KPa):未确定

16. 油水(辛醇/水)分配系数的对数值:未确定

17. 爆炸上限(%,V/V):未确定

18. 爆炸下限(%,V/V):未确定

19. 溶解性:未确定


SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: Verruculogen solution
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances



SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Eye irritation (Category 2), H319
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
F Highly flammableR11
Xn HarmfulR20/21/22
Xi IrritantR36
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal wordDanger
Hazard statement(s)
H225Highly flammable liquid and vapour.
H302 + H312 + H332Harmful if swallowed, in contact with skin or if inhaled
H319Causes serious eye irritation.
Precautionary statement(s)
P210Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280Wear protective gloves/ protective clothing.
P305 + P351 + P338IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazardnone
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)F Highly flammable
Xn Harmful
R-phrase(s)
R11Highly flammable.
R20/21/22Harmful by inhalation, in contact with skin and if swallowed.
R36Irritating to eyes.
S-phrase(s)
S16Keep away from sources of ignition - No smoking.
S26In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36/37Wear suitable protective clothing and gloves.
Other hazards - none

SECTION 3: Composition/information on ingredients
Mixtures
Molecular Weight: 511,57 g/mol
Hazardous ingredients according to Regulation (EC) No 1272/2008
ComponentClassificationConcentration
Acetonitrile
CAS-No.75-05-8Flam. Liq. 2; Acute Tox. 4; Eye 50 - 100 %
EC-No.200-835-2Irrit. 2; H225, H302 + H312 +
Index-No.608-001-00-3H332, H319
Registration number01-2119471307-38-XXXX
Verruculogen from Penicillium verruculosum
CAS-No.12771-72-1Acute Tox. 3; H301, H311,10 - 20 %
H331
Hazardous ingredients according to Directive 1999/45/EC
ComponentClassificationConcentration
Acetonitrile
CAS-No.75-05-8F, Xn, R11 - R20/21/22 - R3650 - 100 %
EC-No.200-835-2
Index-No.608-001-00-3
Registration number01-2119471307-38-XXXX
Verruculogen from Penicillium verruculosum
CAS-No.12771-72-1T, R23/24/2510 - 20 %
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature: -20 °C
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
of protective equipment must be selected according to the concentration and amount of the
dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) AppearanceForm: liquid
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingno data available
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evapouration rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks. Extremes of temperature and direct sunlight.
Incompatible materials
acids, Bases, Oxidizing agents, Reducing agents, Alkali metals
Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available

SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

SECTION 13: Disposal considerations
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: 1648IMDG: 1648IATA: 1648
UN proper shipping name
ADR/RID: ACETONITRILE, SOLUTION
IMDG: ACETONITRILE, SOLUTION
IATA:Acetonitrile, SOLUTION
Transport hazard class(es)
ADR/RID: 3IMDG: 3IATA: 3
Packaging group
ADR/RID: IIIMDG: IIIATA: II
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available

SECTION 15: Regulatory information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
For this product a chemical safety assessment was not carried out

SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
Acute Tox.Acute toxicity
Eye Irrit.Eye irritation
Flam. Liq.Flammable liquids
H225Highly flammable liquid and vapour.
H301Toxic if swallowed.
H302Harmful if swallowed.
H302 + H312 +Harmful if swallowed, in contact with skin or if inhaled
H332
H311Toxic in contact with skin.
H312Harmful in contact with skin.
H319Causes serious eye irritation.
H331Toxic if inhaled.
H332Harmful if inhaled.
Full text of R-phrases referred to under sections 2 and 3
FHighly flammable
TToxic
R11Highly flammable.
R20/21/22Harmful by inhalation, in contact with skin and if swallowed.
R23/24/25Toxic by inhalation, in contact with skin and if swallowed.
R36Irritating to eyes.
XnHarmful
Further information
Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

毒理学数据:

1. 急性毒性:小鼠口服LD50:127mg/kg;小鼠腹腔LD50:2400ug/kg;鸡口服LD50:266mg/kg;鸡腹腔LD50:15200ug/kg;

符号 GHS02 GHS07
GHS02, GHS07
信号词 Danger
危害声明 H225-H302 + H312 + H332-H319
警示性声明 P210-P280-P305 + P351 + P338
危害码 (欧洲) T: Toxic;
风险声明 (欧洲) R23/24/25
安全声明 (欧洲) 36/37/39-45
危险品运输编码 UN 2811 6.1/PG 2
WGK德国 3
RTECS号 JH4920000
海关编码 38220090
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