162849-95-8

• 常用中文名：(2S,3S,5S)-5-(叔丁氧羰基氨基)-2-(N-5-噻唑基甲氧羰基)氨基-1,6-二苯基-3-羟基己烷
• 常用英文名：(2S,3S,5S)-5-(tert-Butoxycarbonylamino)-2-(N-5-thiazolylmethoxycarbonyl)amino-1,6-diphenyl-3-hydroxyhexane
• CAS号：162849-95-8
• 分子式：C₂₈H₃₅N₃O₅S
• 分子量：525.66000
• 发布时间：2019-01-02 20:00:57
• 更新时间：2024-01-08 12:29:42

名称

• 中文名: (2S,3S,5S)-5-(叔丁氧羰基氨基)-2-(N-5-噻唑基甲氧羰基)氨基-1,6-二苯基-3-羟基己烷
• 英文名: tert-Butyl (thiazol-5-ylmethyl) ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate
• 中文别名: 利托那韦中间体; 利托那韦EP杂质J
• 英文别名: (2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino; (2S,3S,5S)-2-amino-5-N-(tert-butoxycarbonyl)-amino-1,6-diphenyl-3-hexanol; (2S,3S,5S)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-5-(t-butyloxycarbonylamino)-1,6-diphenyl-3-hydroxyhexane; (2S,3S,5S)-5-(t-Butyloxycarbonylamino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1.6-diphenyl-3-hydroxyhexane; (2S,3S,5S)-5-tert-ButyloxycarbonylaMino-2-aMino-3-hydroxy-1,6-diphenylhexane; (2S,3S,5S)-5-(Tert-Butyloxycabonyll)aMino-2-aMino-3-Hydroxy-1,6-Dipheny; (2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane; tert-butyl N-[(2S,4S,5S)-5-aMino-4-hydroxy-1,6-diphenylhexan-2-yl]carbaMate; 1,6-diphenyl-5(S)-tert-butoxycarbonylamino-3(S)-hydroxy-2(S)-(5-thiazolemethoxy)carbonylaminohexane; BDH pure salt; tert-butyl (1S,3S,4S)-1-benzyl-3-hydroxy-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentylcarbamate; (2S,3S,5S)-5-(t-butyloxycarbonylamino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-3-hydroxy-1,6-diphenylhexane; (2S,3S,5S)-2-amino-5-[N-[(tert-butyloxy)carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane; (2S,3S,5S)-5-[N-[(tert-butyloxy)carbonyl]amino]-2-[N-[(5-thiazolyl)methoxycarbonyl]amino]-1,6-diphenyl-3-hydroxyhexane; BDH Pure; (2S,3S,5S)-2-amino-3-hydroxy-5-tert-butoxycarbonylamino-1,6-diphenylhexane; (2S,3S,5S)-5-(Tert-Butyloxycabonyll)amino-2-amino-3-Hydroxy-1,6-Diphenyhexane; [(1S,3S,4S)-4-AMino-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]carbaMic acid; (2S,3S,5S)-2-aMino-3-hydroxy-5-(t-butyloxycarbonylaMino-1,6-diphenyl-hexane succinic; (2S,3S,5S)-5-(tert-Butoxycarbonylamino)-2-(N-5-thiazolylmethoxycarbonyl)amino-1,6-diphenyl-3-hydroxyhexane

物化性质

• 分子式: C₂₈H₃₅N₃O₅S
• 分子量: 525.66000
• 精确质量: 525.23000
• PSA: 138.02000
• LogP: 5.64940

合成路线

144163-85-9 144163-97-3 ~92% 162849-95-8

文献：GILEAD SCIENCES, INC.; CULLEN, Aaron, J.; YU, Richard, Hung Chiu Patent: WO2013/116715 A1, 2013 ; Location in patent: Page/Page column 70 ;

1448312-69-3 ~% 1448312-70-6 162849-95-8

文献：GILEAD SCIENCES, INC.; CULLEN, Aaron, J.; YU, Richard, Hung Chiu Patent: WO2013/116715 A1, 2013 ; Location in patent: Page/Page column 71-72 ;

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