144163-97-3

• 常用中文名：((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯
• 常用英文名：4-Nitrophenyl 1,3-thiazol-5-ylmethyl carbonate
• CAS号：144163-97-3
• 分子式：C₁₁H₈N₂O₅S
• 分子量：280.257
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-12-20 20:07:19
• 更新时间：2026-06-30 11:47:59

名称

• 中文名: ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯
• 英文名: ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
• 中文别名: 噻唑基甲基-4-硝基苯碳酸酯; 利托那韦中间体NCT; ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯(易制爆); 5-羟甲基噻唑衍生物(利托那韦中间体); [(5-噻唑基)]甲基-(4-硝基苯基)碳酸酯; ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯 利托那韦中间体; 4-硝基苯-5-甲基噻唑碳酸酯; 4-硝基苯基(噻唑-5-基甲基)碳酸酯; 噻唑基甲基-4-硝基苯基碳酸酯; ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯 (5-噻唑基)甲基-(4-硝基)苯基碳酸酯; 5-羟甲基噻唑衍生物; (5-噻唑基)甲基-(4-硝基)苯基碳酸酯; 利托那韦中间体2; ((5-噻唑基)甲基)-(4-硝基苯基)碳酸酯(NCT); 利托那韦中间2; 4-硝基苯基-5-甲基噻唑碳酸酯
• 英文别名: 4-Nitrophenyl (thiazol-5-ylMethyl) cbonate; (5-THIAZOLYL)METHYL-(4-NITROPHENYL)CARBONATE; ((5-THIAZOLYL)METHYL)-(4-NITROPHENYL)CBONATE / RITONAVIR INTERMEDIATE; [(5-Thiazol)Methyl]-(4-nitrophenyl)cbonate; (5-Thiazolyl)methyl-(4-nitrophenyl) cbonate (NPTC); (4-nitrophenyl) 1,3-thiazol-5-ylmethyl carbonate; ((5-Thiazolyl)methyl)-(4-nitrophenyl)cbonate ISO 9001：2015 REACH; ((5-thiazolyl)methyl)-(4-nitrophenyl)cbonate; Carbonic acid, 4-nitrophenyl 5-thiazolylmethyl ester; 4-Nitrophenyl 5-thiazolylmethyl cbonate; ((5-Thiazolyl)methyl)-(4-nitrophenyl)cbonate (NCT); Cbonic acid 4-nitrophenyl 5-thiazolylmethyl este; Ritonavir intermediate/Thiazolylmethyl-4-nitrophenylcbonate; Thiazolylmethyl-4-nitrophenylcbonate; RITONAVIR INTERMEDIATE-A THIOZOLE [CBONIC ACID-4NITROPHENYL-5-THIAZOLYLMETHYLESTER (NCT); cbonic acid 4-nitrophenyl 5-thiazolylmethyl ester; Ritonavir middle 2; ((5-thiazolyl)methyl)-(4-nitrophenyl)cbonate ( for Antiviral Drugs ); T5N CSJ D1OVOR DNW; ((5-Thiazolyl)methyl)-(4-nitrophenyl)cbonate in stock GMP Factory; Carbonic acid 4-nitrophenyl 5-thiazolylmethyl ester; 5-(p-NitrophenoxycbonyloxyMethyl); ((5-thiazolyl)Methyl)-(4-nitrophenyl)cbonate (SC); ((5-Thiazolyl)methyl)-(4-nitrophenyl)cbote; ((5-Isothiazolyl)methyl)-(4-nitrophenyl)cbonate; (4-Nitrophenyl) thiazol-5-ylmethyl carbonate; cbonic acid [4-nitro-2-(5-thiazolylmethyl)phenyl] ester; 4-Nitrophenyl-5-thiazolylcbonic acid methyl ester

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 475.3±45.0 °C at 760 mmHg
• 熔点: 126-127ºC
• 分子式: C₁₁H₈N₂O₅S
• 分子量: 280.257
• 闪点: 241.3±28.7 °C
• 精确质量: 280.015381
• PSA: 122.48000
• LogP: 1.67
• 外观性状: 灰白-黄色固体
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.627
• 储存条件: Refrigerator

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934100090

合成路线

38585-74-9 7693-46-1 ~80% 144163-97-3

文献：Abbott Laboratories Patent: EP1170289 A2, 2002 ; Location in patent: Page 45 ;

38585-74-9 5070-13-3 ~% 144163-97-3

文献：WO2008/10921 A2, ; Page/Page column 188-189 ;

109-02-4 38585-74-9 7693-46-1 ~75% 144163-97-3

文献：Abbott Laboratories Patent: US5559158 A1, 1996 ;

7693-46-1 ~% 144163-97-3

文献：US5773625 A1, ;

上下游产品

上游产品  4
38585-74-9 7693-46-1 5070-13-3 109-02-4
下游产品  3
144164-11-4 162849-95-8 155213-67-5

海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%