144164-11-4

• 常用中文名：(2S,3S,5S)-5-氨基-2-(N-((5-噻唑基)-甲氧羰基)氨基)-1,6-二苯基-3-羟基己烷
• 常用英文名：(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane
• CAS号：144164-11-4
• 分子式：C₂₃H₂₇N₃O₃S
• 分子量：425.544
• 发布时间：2018-12-02 08:50:57
• 更新时间：2026-08-02 19:05:02

名称

• 中文名: (2S,3S,5S)-5-氨基-2-(N-((5-噻唑基)-甲氧羰基)氨基)-1,6-二苯基-3-羟基己烷
• 英文名: Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate
• 中文别名: (2S,3S,5S)-5-氨基-2-(N-((5-噻唑基)-甲氧基羰基)氨基)-1,6-二苯基-3-羟基己烷; (2S,3S,5S)-5-氨基-2-(N-((5-噻唑基)-甲氧羰基)氨基)-3-羟基-1,6-二苯己烷; (2S,3S,5S)-5-氨基-2-(N-((5-噻唑基)-甲氧基羰基)氨基)-1,6-二苯基-3-羟基己; 利托那韦杂质26; 噻唑-5-基甲基 ((2S,3S,5S)-5-氨基-3-羟基-1,6-二苯基己-2-基)氨基甲酸酯; 利托那韦中间6; 利托那韦中间体
• 英文别名: Thiazol-5-ylmethyl [(1S,2S,4S)-4-Amino-1-benzyl-2-hydroxy-5-phenylpentyl]cbamate; Cbamic acid,N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-,5-thiazolylmethyl ester; (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycbonyl)amino)-1,6-diphenyl-3-hydroxyhexane###144-4; Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2; Thiazol-5-ylMethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)cbaMate; 2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane; (5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)cbamic acid; 1,3-Thiazol-5-ylmethyl n-[(2s,3s,5s)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl]cbamate; (2S,3S,5S)-5-Amino-2-(N-((5-Thiazolyl)-Methoxycbonyl)Amino)-3-Hydroxy-1,6-Diphenylhexane; 1,3-Thiazol-5-ylmethyl [(2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl]carbamate; RitovirImpurity20; Ritonavir Intermediate 2; Falecalcitriol Impurity 28; N-(5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)cbamic acid 5-thiazolylmethyl ester; RT-10; 1,3-Thiazol-5-ylmethyl [(2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenyl-2-hexanyl]carbamate; (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycbonyl)amino; Carbamic acid, N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-, 5-thiazolylmethyl ester; 1,3-Thiazol-5-ylMethyl N-[(1S,2S,4S)-4-amino-1-benzyl-2-hydroxy-5-phenylpentyl]c baMate; 2S,3S,5S-5-AMINO-2-[N-[[(5-THIAZOLYL)METHOXY]carbonyl]AMINO]-1,6-DIPHENYL-3-HYDROXYHEXANE; RIT-X; Ritonavir Impurity 1; amino-3-hydroxy-1,6-diphenylhexan-2-yl)cbamate; Ritonavir Impurity 26; thiazol-5-ylmethyl (5-amino-1,6-diphenylhexan-2-yl)cbamate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 656.1±55.0 °C at 760 mmHg
• 分子式: C₂₃H₂₇N₃O₃S
• 分子量: 425.544
• 闪点: 350.6±31.5 °C
• 精确质量: 425.177307
• PSA: 125.71000
• LogP: 3.27
• 外观性状: 淡黄色油状
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.620
• 储存条件: 2-8℃，惰性气体，避光

安全

• 危害码 (欧洲): Xi

合成路线

162849-95-8 ~96% 144164-11-4

文献：ABBOTT LABORATORIES Patent: WO2008/27932 A2, 2008 ; Location in patent: Page/Page column 96 ; WO 2008/027932 A2

144163-44-0 144163-97-3 ~15% 144164-11-4

文献：Abbott Laboratories Patent: US5559158 A1, 1996 ;

144163-44-0 144163-97-3 98-80-6 ~69% 144164-11-4

文献：Abbott Laboratories Patent: US5559158 A1, 1996 ;

144163-97-3 165315-39-9 ~% 144164-11-4

文献：Journal of the American Chemical Society, , vol. 121, # 6 p. 1145 - 1155

上下游产品

上游产品  5
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