106612-94-6

• 常用中文名：人胰高血糖素样肽-1
• 常用英文名：GLP-1 (7-37)
• CAS号：106612-94-6
• 分子式：C₁₅₁H₂₂₈N₄₀O₄₇
• 分子量：3355.666
• 相关类别： 生物化工 多肽
• 发布时间：2018-05-24 08:00:00
• 更新时间：2026-06-30 11:46:20
• GLP-1(7-37) 是一种肠道胰岛素激素,可以增强葡萄糖诱导的胰岛素分泌。

名称

• 中文名: 人胰高血糖素样肽-1
• 英文名: h-his-ala-glu-gly-thr-phe-thr-ser-asp-val-ser-ser-tyr-leu-glu-gly-gln-ala-ala-lys-glu-phe-ile-ala-trp-leu-val-lys-gly-arg-gly-oh
• 中文别名: 胰高血糖素样肽 - 1醋酸盐; GLP-1醋酸盐; GLP-1人胰高血糖素样肽-1; GLP-1杂质; 人胰高血糖素样肽; GLP-1 ACETATE 醋酸人胰高血糖素样肽-1; 胰高血糖素样肽; 人,牛,豚鼠,小鼠,大鼠GLP-1 肽; 醋酸人胰高血糖素样肽-1 GLP-1ACETATE; 醋酸人胰高血糖素样肽-1; 醋酸人胰高血糖素样肽-1 GLP-1; 胰高血糖素样肽-1(GLP-1); (5S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,50S,53S,56S,59S,62S,65S,68S,71S,74S,77S,80S,86S)-20-((1H-吲哚-3-基)甲基)-86-((S)-2-((S)-2-氨基-3-(1H-咪唑-5-基)丙酰氨基)丙酰氨基)-44-(3-氨基-3-氧代丙基)-11,35-双(4-氨基丁基)-29,77-二苄基-26-((S)-仲丁基)-32,50-双(2-羧乙基)-68-(羧甲基)-5-(3-胍; (5S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,50S,53S,56S,59S,62S,65S,68S,71S,74S,77S,80S,86S)-20-((1H-吲哚-3-基)甲基)-86-((S)-2-((S)-2-氨基-3-(1H-咪唑-5-基)丙酰氨基)丙酰氨基)-44-(3-氨基-3-氧代丙基)-11,35-双(4-氨基丁基)-29,77-二苄基-26-((S)-仲丁基)-32,50-双(2-羧乙基)-68-(羧甲基)-5-(3-胍丙基)-56-(4-羟基苄基)-74,80-双((R)-1-羟乙基)-59,62,71-三(羟甲基)-17,53-二异丁基-14,65-二异丙基-23,38,41-三甲基-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67
• 英文别名: H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-G-GLY-OH //BP; GLP-1, Insulinotropin; TIANFUCHEM-106-6--H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-G-GLY-OH; Proglucagon (huMan, bovine, guinea pig, Mouse, rat), Glucagon-Like Ptide 1 (huMan, bovine, guinea pig, Mouse, rat), Insulinotropin (huMan, bovine, guinea pig, Mouse, rat), Prroglucagon (huMan, bovine, guinea pig, Mouse, rat); GLP-1 (HUMAN, ) (BOVINE, CANINE, RAT, GUINEA PIG); Tglp-1; PRROGLUCAGON HUMAN; GLP-1 , Human, Mouse, Rat, Bovine, Guinea Pig; GLP-1 acetate salt; GLP-1(7-37); Glp-I; Glucagon like ptide I; GLUCAGON-LIKE PTIDE 1; PROGLUCAGON (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT); HuMan GLP-1; Glucagon-Like Ptide (GLP) I; Insulinotropin (human); Prroglucagon; PREPROGLUCAGON 78-108 HUMAN; H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR- LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-LE-ALA-TRP-LEU-VAL- LYS-GLY-G-GLY-OH; GLP-1 (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT); GLUCAGON LIKE PTIDE-I , HUMAN; H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GL; GLP-1 (huMan, bovine, guinea pig, Mouse, rat) Proglucagon (huMan, bovine, guinea pig, Mouse, rat), Insulinotropin (huMan, bovine, guinea pig, Mouse, rat), Glucagon-Like Ptide 1 (huMan, bovine, guinea pig, Mouse, rat), Prroglucag; GLP-1 Prroglucagon; GLUCAGON-LIKE PTIDE 1, FRAGMENT HUMAN; HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-G-GLY; H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-g-Gly-OH acetate salt; GLUCAGON-LIKE PTIDE 1 (HUMAN, ) (BOVINE, CANINE, RAT, GUINEA PIG); Glucagon-related ptide (oncorhynchus kisutch), 3-L-glutamic acid-6-L-phenylalanine-9-L-asptic acid-12-L-serine-15-L-glutamic acid-16-glycine-21-L-isoleucine-24-L-alanine-27-L-valine-28-L-lysine-31-glycine; GLUCAGON-LIKE PTIDE 1 (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT); INSULINOTROPIN (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT); Preproglucagon 78-108; L-Histidyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alany
 l-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-N-(diaminomethylene)-L-ornithylglycine; Glucagon-liktide; GLP-1 impurity; Glucagon-Like Ptide-1 |GLP-1 (human, bovine, guinea pig, mouse, rat); l-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alany; Insulinotropin acetate [GLP-1; Glucagon-like ptide I (human); GLP-1 (7-37) Acetate; HAEGTFTSDVSSYLEGQAAKEFIAWLVKG; GLP-1; GLUCAGON-LIKE PTIDE 1 (HUMAN); Proglucagon (huMan, bovine, guinea pig, Mouse, rat), Insulinotropin (huMan, bovine, guinea pig, Mouse, rat), Glucagon-Like Ptide 1 (huMan, bovine, guinea pig, Mouse, rat), Prroglucagon (huMan, bovine, guinea pig, Mouse, rat); PRROGLUCAGON (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT); GLP-1 (HUMAN); HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG; HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY; (5S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,50S,53S,56S,59S,62S,65S,68S,71S,74S,77S,80S,86S)-20-((1H-Indol-3-yl)methyl)-86-((S)-2-((S)-2-amino-3-(1H-imidazol-5-yl)propanamido)propanamido)-44-(3-amino-3-oxopropyl)-11,35-bis(4-aminobutyl)-29,77-dibenzyl-26-((S)-sec-butyl)-32,50-bis(2-cboxyethyl)-68-(cboxymethyl)-5-(3-guanidinopropyl)-56-(4-hydroxybenzyl)-74,80-bis((R)-1-hydroxyethyl)-59,62,71-tris(hydroxymethyl)-17,53-diisobutyl-14,65-diisopropyl-23,38,41-trimethyl-4,7,10,13,16,19,22,2; GLP-1,HAEGTFTSDVSSYLEGQAAKEFIAWLVKG; insulinotropin; H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-G-GLY-OH; GLP-1 Acetate | Glucagon-Like Ptide 1; Human GLP-1; Human GLP-1 (7-37); Glucagon-Like Ptide 1, GLP-1 human, mouse, rat, bovine, guinea pig; (5S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,50S,53S,56S,59S,62S,65S,68S,71S,74S,77S,80S,86S)-20-((1H-Indol-3-yl)methyl)-86-((S)-2-((S)-2-amino-3-(1H-imidazol-5-yl)propanamido)propanamido)-44-(3-amino-3-oxopropyl)-11,35-bis(4-aminobutyl)-29,77-dibenzyl-26-((S)-sec-butyl)-32,50-bis(2-cboxyethyl)-68-(cboxymethyl)-5-(3-guanidinopropyl)-56-(4-hydroxybenzyl)-74,80-bis((R)-1-hydroxyethyl)-59,62,71-tris(hydroxymethyl)-17,53-diisobutyl-14,65-diisopropyl-23,38,41-trimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76,79,82,85-octacosaoxo-3,6,9,12,15,18,21,24,27,30; Ptide GLP-1 (human glucose-lowering ptide-1); GLP-1,7-37

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₅₁H₂₂₈N₄₀O₄₇
• 分子量: 3355.666
• 精确质量: 3353.667969
• PSA: 1408.40000
• LogP: -3.86
• 折射率: 1.660
• 储存条件: −20°C
• 水溶解性: Soluble in water at 2mg/ml

生物活性

• 描述: GLP-1(7-37) 是一种肠道胰岛素激素,可以增强葡萄糖诱导的胰岛素分泌。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胰高血糖素受体
  研究领域 >> 其他
  多肽产品
• 体内研究: GLP-1(7-37)是一种肠促胰岛素激素,可增加葡萄糖诱导的胰岛素分泌[1]。在Sprague-Dawley大鼠的2小时11mmol/L高血糖钳夹的第二小时内以0.5,5或50pmol/min/kg静脉内(IV)输注GLP-1(7-37)产生剂量相关增强葡萄糖诱导的血浆胰岛素浓度增加。在高血糖钳夹期间输注GLP-1(7-37)(5 pmol/min/kg IV),两次连续增加的葡萄糖浓度为11和17 mmol/L,胰岛素分别增加600和1,200 pM。 。类似地,在高胰岛素血症,高血糖Zucker糖尿病性脂肪(ZDF)大鼠中输注GLP-1(7-37)产生血浆胰岛素浓度的短暂增加并使血浆葡萄糖浓度正常化。 GLP-1(7-37)在大鼠中的输注维持在11mM葡萄糖导致血浆胰岛素浓度持续大约两倍的增强。在以15pmol/min/kg输注GLP-1(7-37)5天的大鼠中,基础血浆胰岛素浓度略有增加并且对葡萄糖没有影响[2]。
• 动物实验: 大鼠[2]所有实验均在体重为300至350g的有意识的，导管插入的雄性Sprague-Dawley大鼠或对照大鼠（体重，分别为280至320和220至260g）中进行。在2小时11mM高血糖钳夹的第二小时期间，以0.5,5或50pmol / min / kg IV输注GLP-1（7-37）。以可变速率输注葡萄糖（50％溶液）以将血浆葡萄糖浓度维持在11mM。将GLP-1（7-37）（5pmol / rnin / kg）或载体（2％热灭活的血清加1％生理盐水中的乙酸钠）通过颈静脉导管输注60分钟[2]。
• 参考文献:

  [1]. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004).

  [2]. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7.

安全

• 安全声明 (欧洲): 22-24/25
• WGK德国: 3