469-32-9

• 常用中文名：金缕梅单宁
• 常用英文名：Hamamelitannin
• CAS号：469-32-9
• 分子式：C₂₀H₂₀O₁₄
• 分子量：484.364
• 相关类别： 生物化工 天然产物
• 发布时间：2018-09-11 23:22:25
• 更新时间：2026-07-16 22:55:15
• Hamamelitannin 是从 Hamamelis virginiana 树皮中提取的多酚,是一种群体感应 (QS) 抑制剂。Hamamelitannin 通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。

名称

• 中文名: 金缕梅单宁
• 英文名: hamamelitannin
• 中文别名: 金缕梅丹宁酸; 金缕梅单宁酸; 七叶树鞣质; 金缕梅素
• 英文别名: 2',5-DigalloylhaMaMelofuranose; Hamamelofuranose 2μ,5-digallate, 2-C-(Hydroxymethyl)-D-ribofuranose 2μ,5-digallate; cancer,TRAP,Hamamelitannin,suppressor,Bacterial,ptidoglycan,colon,quorum-sensing,antibiotic,Inhibitor,cytotoxic,cells,infections,inhibit; [(2R,3R,4R)-3,4,5-Trihydroxytetrahydrofuran-2,4-diyl]bis(methylen)bis(3,4,5-trihydroxybenzoat); HAMAMELITANNIN; Bis(3,4,5-trihydroxybenzoate) de [(2R,3R,4R)-3,4,5-trihydroxytétrahydrofurane-2,4-diyl]bis(méthylène); 2',5-digalloylhamamelose; 2-C-[(galloyloxy)methyl]-D-ribose 5-gallate; Aids-070888; O5-Galloyl-2-galloyloxymethyl-D-ribose; 5-O-(3,4,5-Trihydroxybenzoyl)-2-C-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}-D-ribofuranose; 2-C-(Hydroxymethyl)-D-ribofuranose 2',5-Digallate; HAMAMELOFURANOSE 2',5-DIGALLATE; 2,3-Digalloylglucose; 2-[[(3,4,5-Trihydroxybenzoyl)oxy]methyl]-D-ribose 5-(3,4,5-trihydroxybenzoate); D-Ribose, 2-C-[[(3,4,5-trihydroxybenzoyl)oxy]methyl]-, 5-(3,4,5-trihydroxybenzoate); 2-C-[[(3,4,5-Trihydroxybenzoyl)oxy]methyl]-D-ribofuranose 5-(3,4,5-trihydroxybenzoate); HAMAMELITANNIN //BP; hamamelitanin; 3,4,5-trihydroxybenzoic acid [(2R,3R,4R)-3,4,5-trihydroxy-4-[[oxo-(3,4,5-trihydroxyphenyl)methoxy]methyl]-2-oxolanyl]methyl ester; Aids070888; Hamamelitannin-RM; Chinese Witchhazel Extract; [(2R,3R,4R)-3,4,5-Trihydroxytetrahydrofuran-2,4-diyl]bis(methylene) bis(3,4,5-trihydroxybenzoate); 2-C-(HYDROXYMETHYL)-D-RIBOFURANOSE 2',5-DIGALLATE; D-Ribofuranose, 2-C-[[(3,4,5-trihydroxybenzoyl)oxy]methyl]-, 5-(3,4,5-trihydroxybenzoate)

物化性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 941.7±65.0 °C at 760 mmHg
• 熔点: 145-147ºC
• 分子式: C₂₀H₂₀O₁₄
• 分子量: 484.364
• 闪点: 329.0±27.8 °C
• 精确质量: 484.085297
• PSA: 243.90000
• LogP: 2.91
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.746
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Hamamelitannin 是从 Hamamelis virginiana 树皮中提取的多酚,是一种群体感应 (QS) 抑制剂。Hamamelitannin 通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 金缕梅素显示对结肠癌细胞特异的细胞毒活性〔3〕。
• 参考文献:

  [1]. Kiran MD, et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol. 2008 May;73(5):1578-86.

  [2]. Cobrado L, et al. In vivo antibiofilm effect of cerium, chitosan and hamamelitannin against usual agents of catheter-related bloodstream infections. J Antimicrob Chemother. 2013 Jan;68(1):126-30.

  [3]. Sánchez-Tena S, et al. Hamamelitannin displays specific cytotoxic activity against colon cancer cells. J Nat Prod. 2012 Jan 27;75(1):26-33.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3