1258392-53-8

1258392-53-8结构式

中文名	AZD5582
英文名	(2S,2'S)-N,N'-{2,4-Hexadiyne-1,6-diylbis[oxy(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]}bis{1-[(2S)-2-cyclohexyl-2-{[(2S)-2-(methylamino)propanoyl]amino}acetyl]-2-pyrrolidinecarboxamide} (non-preferred name)
中文别名	(2S,2'S)-1,1'-((S,2S,2'S)-2,2'-(((1S,1'S,2R,2'R)-(己-2,4-二炔-1,6-二基双(氧))双(2,3-二氢-1H-茚-2,1-二基))双(环己烷-3,1-二基))双(2-((S)-2-(甲胺基)丙胺基)乙酰基)双(吡咯烷-2-甲酰胺) AZD5582试剂二聚化SMAC MIMETICS,IAPS抑制剂
英文别名	(2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-cboxamide) 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide] (2S,2'S)-1,1'-((S,2S,2'S)-2,2'-(((1S,1'S,2R,2'R)-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(cyclohexane-3,1-diyl))bis(2-((S)-2-(methylamino)propanamido)acetyl))bis(pyrrolidine-2-cboxamide) AZD-5582 L-Prolinamide, 3,3'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl (S,S,2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-cboxamide) AZD5582;AZD-5582;AZD AZD5582 ，S7362 ZD5582

描述	AZD5582是二聚化Smac mimetics,IAPs抑制剂,对cIAP1,cIAP2和XIAP的IC50值分别为15,21和15nM。
相关类别	信号通路 >> 细胞凋亡 >> IAP 研究领域 >> 癌症
参考文献	[1]. Hennessy EJ, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919. [2]. Zhuang J, et al. Selective IAP inhibition results in sensitization of unstimulated but not CD40-stimulated chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis. Pharmacol Res Perspect. 2014 Dec;2(6):e00081.