1448754-43-5

• 常用中文名：盐酸Eleclazine
• 常用英文名：Eleclazine hydrochloride
• CAS号：1448754-43-5
• 分子式：C₂₁H₁₇ClF₃N₃O₃
• 分子量：451.826
• 相关类别： 信号通路 跨膜转运 钠通道
• 发布时间：2018-02-24 12:31:27
• 更新时间：2024-01-02 16:34:27
• Eleclazine hydrochloride是一个新的Na+电流的抑制剂，IC50值是0.7 uM.

名称

• 中文名: 盐酸Eleclazine
• 英文名: Eleclazine hydrochloride
• 英文别名: 1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-, hydrochloride (1:1); 4-(2-Pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-1,4-benzoxazepin-5(2H)-one hydrochloride (1:1); 4R1JP3Q4HI; ELECLAZINE HYDROCHLORIDE; Eleclazine (hydrochloride)

物化性质

• 分子式: C₂₁H₁₇ClF₃N₃O₃
• 分子量: 451.826
• 精确质量: 451.091064
• 储存条件: 2-8℃

生物活性

• 描述: Eleclazine hydrochloride是一个新的Na+电流的抑制剂,IC50值是0.7 uM.
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 其他
• 参考文献:

  [1]. Rajamani S et al. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. Br J Pharmacol. 2016 Jul 23.

  [2]. Justo F et al. Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent a