盐酸Eleclazine

• 常用名: 盐酸Eleclazine
• 英文名: Eleclazine hydrochloride
• CAS号: 1448754-43-5
• 分子量: 451.826
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₇ClF₃N₃O₃
• 熔点: N/A
• 闪点: N/A

盐酸Eleclazine用途

Eleclazine hydrochloride是一个新的Na+电流的抑制剂,IC50值是0.7 uM.

盐酸Eleclazine名称

• 中文名: 盐酸Eleclazine
• 英文名: Eleclazine hydrochloride

盐酸Eleclazine生物活性

• 描述: Eleclazine hydrochloride是一个新的Na+电流的抑制剂,IC50值是0.7 uM.
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 其他
• 参考文献:

  [1]. Rajamani S et al. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. Br J Pharmacol. 2016 Jul 23.

  [2]. Justo F et al. Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent a

盐酸Eleclazine物理化学性质

• 分子式: C₂₁H₁₇ClF₃N₃O₃
• 分子量: 451.826
• 精确质量: 451.091064
• InChIKey: ZRYHNOXHGYUHFF-UHFFFAOYSA-N
• SMILES: Cl.O=C1c2cc(-c3ccc(OC(F)(F)F)cc3)ccc2OCCN1Cc1ncccn1
• 储存条件: 2-8℃

盐酸Eleclazine英文别名

• 1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-, hydrochloride (1:1)
• 4-(2-Pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-1,4-benzoxazepin-5(2H)-one hydrochloride (1:1)
• 4R1JP3Q4HI
• ELECLAZINE HYDROCHLORIDE
• Eleclazine (hydrochloride)