1356354-25-0

1356354-25-0结构式

中文名	纳夫西林-d5钠盐
英文名	Sodium (2S,5R,6R)-6-({2-[(2H5)ethyloxy]-1-naphthoyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
英文别名	Sodium (2S,5R,6R)-6-({2-[(2H5)ethyloxy]-1-naphthoyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[2-(ethyl-d5-oxy)-1-naphthalenyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)- (1:1)

描述	萘西林-d5钠是氘标记的萘西林钠。萘西林钠是一种抗生素,是一种可逆的β-内酰胺酶抑制剂。萘西林钠可用于葡萄球菌感染的研究[1][2]。
相关类别	研究领域 >> 感染
体外研究	氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tan AK, et, al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):191-6. [3]. Palmer DL, et, al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg. 1995 Mar;59(3):626-31. [4]. Lawrence I. Mortin, et al. Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria. Antimicrob Agents Chemother. 2007 May; 51(5): 1787-1794.