1258063-56-7

• 常用中文名：脱氧可的松-2,2,4,6,6-d5
• 常用英文名：Cortodoxone-d5
• CAS号：1258063-56-7
• 分子式：C₂₁H₂₅D₅O₄
• 分子量：351.491
• 发布时间：2018-07-10 01:58:49
• 更新时间：2026-07-01 16:00:07
• 可的松-d5(11-脱氧可的松-d5)是氘标记的可的松。

名称

• 中文名: 脱氧可的松-2,2,4,6,6-d5
• 英文名: 11-Deoxycortisol-[D5]
• 中文别名: 11-脱氧皮质醇-/精确称量; 甲醇中11-脱氧皮质醇-[D5]; 11-去氧甲固醇(2,2,4,6,6-D5,)度; 11-去氧甲固醇(2,2,4,6,6-D5); 甲醇中11-脱氧皮质醇-D5同位素; 氘5-11-去氧皮质醇; 11-脱氧皮质醇-2,2,4,6,6-D; 11-去氧甲固醇 (2,2,4,6,6-D5, ) 100UG/ML溶于甲醇; 2H5]-11-脱氧皮质醇; 11-脱氧皮质醇-[D5]; 11-脱氧皮质醇-[D5] (溶液); 脱氧可的松-D5; 11-脱氧皮质醇L-2,2,4,6,6-D
• 英文别名: 11-Deoxycortisol (2,2,4,6,6-D, ) 100 μg/mL in methanol; Cortexolone-2,2,4,6,6-d5; 11-Deoxycortisol-2,2,4,6,6-d; 11-DEOXYCORTISOL-2,2,4,6,6-D5; 17,21-Dihydroxy(2,2,4,6,6-2H5)pregn-4-ene-3,20-dione; Deoxycortisol-[d5]; Reichstein's substance S (2,2,4,6,6-d5); 11-Deoxycortisol-2,2,4,6,6-d5; 11-DEOXYCORTISOL (2,2,4,6,6-D5, ) CHEMICAL PURITY; 11-Deoxycortisol-[D5] (CertiMass solution); 11-Desoxycortisol-D5 (2,2,4,6,6-D5); 11-DEOXYCORTISOL (2,2,4,6,6-D5, ) 100 UG/ML IN METHANOL; 11-Deoxycortisol (2,2,4,6,6-D, ); Cortodoxone-D5 (2,2,4,6,6-D5); EINECS 200-659-6; 11-Deoxy-17-hydroxycorticosterone-2,2,4,6,6-d5; 2H5]-11-Deoxy cortisol; 11-Deoxycortisol-[d5] (Solution); 17,21-Dihydroxyprogesterone-2,2,4,6,6-d5; 11-Deoxycortisol-D5 (2,2,4,6,6-D5) solution; D5-11-Deoxy cortisol; 11-Deoxycortisol-[d5] in Methanol; 11-Deoxycortisol-2,2,4,6,6-d5 98 atom % D; 11-Deoxycortisol-D5 (2,2,4,6,6-D5); MFCD15144809

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 524.5±50.0 °C at 760 mmHg
• 熔点: 208 °C (dec.)
• 分子式: C₂₁H₂₅D₅O₄
• 分子量: 351.491
• 闪点: 285.1±26.6 °C
• 精确质量: 351.245789
• LogP: 2.74
• 外观性状: 固体
• 蒸汽压: 0.0±3.1 mmHg at 25°C
• 折射率: 1.578
• 储存条件: 20°C

生物活性

• 描述: 可的松-d5(11-脱氧可的松-d5)是氘标记的可的松。
• 相关类别:
  研究领域 >> 内分泌
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

安全

• 危险品运输编码: NONH for all modes of transport