1257116-00-9

• 常用中文名：RQ-00311651
• 常用英文名：RQ-00311651
• CAS号：1257116-00-9
• 分子式：C₁₉H₁₈F₃N₅O₂
• 分子量：405.374
• 发布时间：2021-01-10 14:08:51
• 更新时间：2023-03-04 11:35:24
• RQ-00311651 is a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain. RQ-00311651 strongly suppressed T currents when tested at holding potentials of -65 ～ -60 mV, but not -80 mV, in the Cav3.1- or Cav3.2-expressing cells. RQ-00311651 also inhibited high K-induced Ca signaling in those cells.

名称

• 英文名: (1S,2S)-2-(1H-Benzimidazol-2-yl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyrazinyl]ethyl}cyclopropanecarboxamide
• 英文别名: (1S,2S)-2-(1H-Benzimidazol-2-yl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyrazinyl]ethyl}cyclopropanecarboxamide; Cyclopropanecarboxamide, 2-(1H-benzimidazol-2-yl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyrazinyl]ethyl]-, (1S,2S)-

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 655.8±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈F₃N₅O₂
• 分子量: 405.374
• 闪点: 350.4±31.5 °C
• 精确质量: 405.141266
• LogP: 1.63
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.609