1257116-00-9

1257116-00-9 structure

Name: RQ-00311651
Chemical Name: (1S,2S)-2-(1H-Benzimidazol-2-yl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyrazinyl]ethyl}cyclopropanecarboxamide
CAS Number: 1257116-00-9
Molecular Formula: C₁₉H₁₈F₃N₅O₂
Molecular Weight: 405.374
Create Date: 2021-01-10 14:08:51
Modify Date: 2024-10-01 11:34:19
RQ-00311651 is a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain. RQ-00311651 strongly suppressed T currents when tested at holding potentials of -65 ～ -60 mV, but not -80 mV, in the Cav3.1- or Cav3.2-expressing cells. RQ-00311651 also inhibited high K-induced Ca signaling in those cells.

Name	(1S,2S)-2-(1H-Benzimidazol-2-yl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyrazinyl]ethyl}cyclopropanecarboxamide
Synonyms	(1S,2S)-2-(1H-Benzimidazol-2-yl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyrazinyl]ethyl}cyclopropanecarboxamide Cyclopropanecarboxamide, 2-(1H-benzimidazol-2-yl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyrazinyl]ethyl]-, (1S,2S)-