1284150-65-7

• 常用中文名：Azeliragon HCl
• 常用英文名：Azeliragon HCl
• CAS号：1284150-65-7
• 分子式：C₃₂H₄₀Cl₃N₃O₂
• 分子量：605.038
• 发布时间：2021-01-08 18:03:38
• 更新时间：2024-01-19 13:57:00
• Azeliragon, also known as TTP488 and PF-04494700, is a potent and orally active RAGE inhibitor. RAGE (receptor for advanced glycation endproducts) is a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon is a promising agent for for Alzheimer's disease and cerebral amyloid angiopathy.

名称

• 英文名: 3-(4-{2-Butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl}phenoxy)-N,N-diethyl-1-propanamine dihydrochloride
• 英文别名: 1-Propanamine, 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]-N,N-diethyl-, hydrochloride (1:2); 3-(4-{2-Butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl}phenoxy)-N,N-diethyl-1-propanamine dihydrochloride

物化性质

• 分子式: C₃₂H₄₀Cl₃N₃O₂
• 分子量: 605.038
• 精确质量: 603.218628