1821798-25-7

1821798-25-7结构式

常用中文名：GSK-LSD1二盐酸盐
常用英文名：GSK-LSD1 dihydrochloride
CAS号：1821798-25-7
分子式：C₁₄H₂₂Cl₂N₂
分子量：289.244
发布时间：2021-01-10 09:54:13
更新时间：2024-01-02 16:04:50
GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. GSK-LSD1 inhibits LSD1 with an IC50 of 16 nM and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Lysine specific demethylase 1 (LSD1) is a histone demethylase found in various transcriptional co-repressor complexes. LSD1 is involved in ES cell differentiation, hematopoiesis, and has been described as having a role in Acute Myeloid Leukemia (AML). (http://www.thesgc.org/chemical-probes/GSK-LSD1)

中文名	GSK-LSD1二盐酸盐
英文名	GSK-LSD1 (hydrochloride)
英文别名	N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride GSK-LSD1 (hydrochloride) 4-Piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-, hydrochloride (1:2)