GSK-LSD1二盐酸盐

• 常用名: GSK-LSD1二盐酸盐
• 英文名: GSK-LSD1 dihydrochloride
• CAS号: 1821798-25-7
• 分子量: 289.244
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₂₂Cl₂N₂
• 熔点: N/A
• 闪点: N/A

GSK-LSD1二盐酸盐用途

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. GSK-LSD1 inhibits LSD1 with an IC50 of 16 nM and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Lysine specific demethylase 1 (LSD1) is a histone demethylase found in various transcriptional co-repressor complexes. LSD1 is involved in ES cell differentiation, hematopoiesis, and has been described as having a role in Acute Myeloid Leukemia (AML). (http://www.thesgc.org/chemical-probes/GSK-LSD1)

GSK-LSD1二盐酸盐名称

• 中文名: GSK-LSD1二盐酸盐
• 英文名: GSK-LSD1 (hydrochloride)

GSK-LSD1二盐酸盐物理化学性质

• 分子式: C₁₄H₂₂Cl₂N₂
• 分子量: 289.244
• 精确质量: 288.115997
• 储存条件: 2-8°C，保存于惰性气体中

GSK-LSD1二盐酸盐英文别名

• N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride
• GSK-LSD1 (hydrochloride)
• 4-Piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-, hydrochloride (1:2)