GSK-LSD1 dihydrochloride
Modify Date: 2024-01-02 16:04:50
GSK-LSD1 dihydrochloride structure
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Common Name | GSK-LSD1 dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1821798-25-7 | Molecular Weight | 289.244 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H22Cl2N2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK-LSD1 dihydrochlorideGSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. GSK-LSD1 inhibits LSD1 with an IC50 of 16 nM and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Lysine specific demethylase 1 (LSD1) is a histone demethylase found in various transcriptional co-repressor complexes. LSD1 is involved in ES cell differentiation, hematopoiesis, and has been described as having a role in Acute Myeloid Leukemia (AML). (http://www.thesgc.org/chemical-probes/GSK-LSD1) |
| Name | GSK-LSD1 (hydrochloride) |
|---|---|
| Synonym | More Synonyms |
| Molecular Formula | C14H22Cl2N2 |
|---|---|
| Molecular Weight | 289.244 |
| Exact Mass | 288.115997 |
| N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride |
| GSK-LSD1 (hydrochloride) |
| 4-Piperidinamine, N-[(1R,2S)-2-phenylcyclopropyl]-, hydrochloride (1:2) |