158792-24-6

• 常用中文名：Collismycin A
• 常用英文名：Collismycin A
• CAS号：158792-24-6
• 分子式：C₁₃H₁₃N₃O₂S
• 分子量：275.32600
• 发布时间：2017-11-18 22:59:37
• 更新时间：2024-01-08 16:56:31
• Collismycin A is a bacterial metabolite with antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria and fungi. It inhibits proliferation of A549 lung, HCT116 colon, HeLa cervical cancer cells, and NIH373 fibroblasts but not MDA-MD-231 breast cancer cells. Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions. Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid.

名称

• 英文名: (2E)-4-methoxy-3-methylsulfanyl-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine
• 英文别名: (E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime; (2,2'-Bipyridine)-6-carboxaldehyde,4-methoxy-5-(methylthio)-,oxime,(E); 4-methoxy-5-methylsulfanyl-[2,2']bipyridinyl-6-carbaldehyde oxime; (E)-4-methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carboxaldehyde oxime; Collismycin A

物化性质

• 密度: 1.27g/cm3
• 沸点: 381.2ºC at 760 mmHg
• 分子式: C₁₃H₁₃N₃O₂S
• 分子量: 275.32600
• 闪点: 184.3ºC
• 精确质量: 275.07300
• PSA: 92.90000
• LogP: 2.68220
• 蒸汽压: 5.16E-06mmHg at 25°C
• 折射率: 1.624

安全

• 海关编码: 2933399090

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%