158792-24-6

158792-24-6 structure

Name: Collismycin A
Chemical Name: (2E)-4-methoxy-3-methylsulfanyl-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine
CAS Number: 158792-24-6
Molecular Formula: C₁₃H₁₃N₃O₂S
Molecular Weight: 275.32600
Create Date: 2017-11-18 22:59:37
Modify Date: 2024-01-08 16:56:31
Collismycin A is a bacterial metabolite with antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria and fungi. It inhibits proliferation of A549 lung, HCT116 colon, HeLa cervical cancer cells, and NIH373 fibroblasts but not MDA-MD-231 breast cancer cells. Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions. Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid.

Name	(2E)-4-methoxy-3-methylsulfanyl-2-(nitrosomethylidene)-6-pyridin-2-yl-1H-pyridine
Synonyms	(E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime (2,2'-Bipyridine)-6-carboxaldehyde,4-methoxy-5-(methylthio)-,oxime,(E) 4-methoxy-5-methylsulfanyl-[2,2']bipyridinyl-6-carbaldehyde oxime (E)-4-methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carboxaldehyde oxime Collismycin A

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%