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79183-19-0

79183-19-0结构式

中文名	1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮
英文名	1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
中文别名	APOPTOSIS活化剂2 (AAII),CYTOCHROME C CASPASE活化剂AND APOPTOSIS INDUCER 抑制剂Apoptosis Activator 2 凋亡激活剂 2 细胞凋亡激活剂2, 一种细胞色素C半胱天冬酶活化剂和凋亡诱导物细胞凋亡激活剂(MDK83190) 凋亡活化剂 2 1-(3,4-二氯苄基)吲哚啉-2,3-二酮 MDK83190(凋亡激活剂)
英文别名	1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione/Apoptosis Activator 2 Apoptosis Activator 2, >= 1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione Apoptosis Activator 2 a cytochrome c caspase activator and apoptosis inducer Apoptosis Activator 2 (AAII), Cytochrome c caspase activator and apoptosis inducer Tocris-2098 1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl] 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione MDK83190 MDK83190, 10 mM in DMSO 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Apoptosis Activator II APOPTOSIS ACTIVATOR 2 APOPTOSIS ACTIVATOR II 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE //BP

描述	Apoptosis Activator 2是细胞凋亡有效激活剂,能促进procaspase-9的加工并活化caspase-3。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 癌症
参考文献	[1]. Nguyen JT, et al. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8. [2]. Hyatt JL, et al. Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.