1440957-55-0

• 常用中文名：Secalciferol-d6
• 常用英文名：Secalciferol-d6
• CAS号：1440957-55-0
• 分子式：C₂₇H₃₈D₆O₃
• 分子量：422.68
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2021-10-26 10:31:47
• 更新时间：2026-07-04 00:29:00
• Secalciferol-d6((24R)-24,25-二羟维生素D3-d6)是氘标记的Secalciferol。Secalciferol是维生素D的代谢物,维生素D可能是一种抗炎类固醇,参与骨骨化[1][2]。

名称

• 中文名: 26,26,26,27,27,H6]-24R,25-二羟基维生素[干冰运输
• 英文名: Secalciferol-d6
• 中文别名: [2H6]-司骨化醇; 司骨化醇-D6; 2H6]-24R,25-二羟基维生素D3; 26,26,26,27,27,H6]-24R,25-二羟基维生素D3; 24R,25-二羟维生素D3(度)
• 英文别名: 24R,25-Dihydroxyvitamin D (26,26,26,27,27,27-D, ) 100 μg/mL in ethanol; [2H6]-Secalciferol; 24R,25-Dihydroxyvitamin D (26,26,26,27,27,27-D, ); 26,26,26,27,27,H6]-24R,25-DihydroxyVitamin D3; (3R,6R)-6-[(1R,3aS,4E,7-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-1,1,1-trideuterio-2-(trideuteriomethyl)htane-2,3-diol; 24,25 Dihydroxyvitamin d3 (26,26,26,27,27,27-d6)

物化性质

• 分子式: C₂₇H₃₈D₆O₃
• 分子量: 422.68

生物活性

• 描述: Secalciferol-d6((24R)-24,25-二羟维生素D3-d6)是氘标记的Secalciferol。Secalciferol是维生素D的代谢物,维生素D可能是一种抗炎类固醇,参与骨骨化[1][2]。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 炎症/免疫
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Yamamoto T, Ozono K, Shima M, et al. 24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 1998 Oct 10;244(1):71-6.

  [3]. Sakaki T, Sawada N, Takeyama K, et al. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 α-hydroxylase expressed in Escherichia coli. Eur J Biochem. 1999 Feb;259(3):731-8.

  [4]. Norman AW, Okamura WH, Bishop JE, Henry HL. Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol. 2002 Nov 29;197(1-2):1-13

  [5]. Hurst-Kennedy J, Zhong M, Gupta V et al. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. J Steroid Biochem Mol Biol. 2010 Oct;122(4):264-71.

  [6]. Wehmeier KR, Alamir AR, Sultan S, et al. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011 Jan 3;88(1-2):110-6.

  [7]. Rubin LP, Yeung B, Vouros P et al. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr Res. 1993 Jul;34(1):98-104.