1217685-27-2

• 常用中文名：度他雄胺
• 常用英文名：Dutasteride-13C6
• CAS号：1217685-27-2
• 分子式：C₂₁₁₃C₆H₃₀F₆N₂O₂
• 分子量：534.49
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2022-10-22 11:59:25
• 更新时间：2026-07-16 16:01:42
• Dutasteride-13C6是13C标记的Dutasteride[1]。杜他星苷(GG745)是两种5α-还原酶同工酶的有效抑制剂。Dutasteride可能对雄激素受体(AR)具有脱靶作用,因为其结构与DHT相似[2]。

名称

• 中文名: 度他雄胺
• 英文名: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
• 英文别名: (1S,3aS,3bS,5,9,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-cboxamide; Dutasteride-13C6 (Contains d0) Discontinued; (4,6aS,7S)-N-(2,5-bis(trifluoromethyl)-3lambda3,4lambda3,6lambda3-phenyl-1,2,3,4,5,C6)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-cboxamide; Dutasteride 13C6Q: What is Dutasteride 13C6 Q: What is the CAS Number of Dutasteride 13C6 Q: What is the storage condition of Dutasteride 13C6 Q: What e the applications of Dutasteride 13C6

物化性质

• 分子式: C₂₁₁₃C₆H₃₀F₆N₂O₂
• 分子量: 534.49
• 储存条件: -20°C

生物活性

• 描述: Dutasteride-13C6是13C标记的Dutasteride[1]。杜他星苷(GG745)是两种5α-还原酶同工酶的有效抑制剂。Dutasteride可能对雄激素受体(AR)具有脱靶作用,因为其结构与DHT相似[2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 5 alpha还原酶
• 体外研究: 氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

  [2]. Lazier CB, et al. Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004 Feb 1;58(2):130-44.

  [3]. Biancolella M, et al. Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25(5):491-7.

  [4]. Bramson HN, et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. J Pharmacol Exp Ther. 1997 Sep;282(3):1496-502.

  [5]. Andriole GL, et al. Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride. J Urol. 2006 May;175(5):1657-62.

  [6]. Margiotta-Casaluci L, et al. Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat Toxicol. 2013 Mar 15;128-129:113-23.