Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Yohimban-16-carboxylicacid, 18-[[4-[(ethoxycarbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxy-,methyl ester, (3b,16b,17a,18b,20a)-
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Purity: 98.0%
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84-36-6

84-36-6 structure

Name: Syrosingopine
Chemical Name: methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
CAS Number: 84-36-6
Molecular Formula: C₃₅H₄₂N₂O₁₁
Molecular Weight: 666.71500
Catalog: Natural product Alkaloid
Create Date: 2018-06-03 08:00:00
Modify Date: 2026-07-05 08:48:55
Syrosingopine (Su 3118) is an antihypertensive agent. Syrosingopine can decrease brain dopamine levels[1][2].

Name	methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Synonyms	Seringina Serpagon reserpicacid,methylester,esterwith4-hydroxy-3,5-dimethoxybenzoicacide cbethoxysyringoylmethyeserpate b-cboline-1-cboxylic acid methyl ester Siringina Londomin 18-[[4-[(Ethoxycbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxy-yohimban-16-cboxylic acid methyl ester thylcbonate Benzoic acid, 4-hydroxy-3,5-dimethoxy-, ethyl cbonate, ester with methyl reserpate Nichiserpine-S MFCD00017411 methyeserpate,4-ethoxycbonyl-3,5-dimethoxybenzoicacidester SYROSINGOPINE benzoicacid,4-hydroxy-3,5-dimethoxy-,ethylcbonate,esterwithmethye 3beta,20alpha-Yohimban-16beta-cboxylic acid, 18beta-hydroxy-11,17alpha-dimethoxy-, methyl ester, ester with 4-hydroxy-3,5-dimethoxybenzoic acid ethyl cbonate Cbethoxysyringoyl methyeserpate Etropres su3118 Siringal Seniramin Syrosingopin Reserpic acid, methyl ester, ester with 4-hydroxy-3,5-dimethoxybenzoic acid ethyl cbonate Methyl reserpate, 4-ethoxycbonyl-3,5-dimethoxybenzoic acid ester Methyl reserpate ester of syringic acid ethyl cbonate methylcbethoxysyringoyeserpate Elufinesin Vegaserpina syringicacidethylcbonateesterwithmethyeserpate Methyl cbethoxysyringoyl reserpate Siriserpin Menatensina 3beta,20alpha-Yohimban-16beta-cboxylic acid, 18beta-hydroxy-11,17alpha-dimethoxy-, methyl ester, 4-hydroxy-3,5-dimethoxybenzoate (ester) ethyl cbonate (ester) bonate Reserpic acid, methyl ester, ester with syringic acid, ethyl cbonate (6CI) imethoxy-,methylester,esterwith4-hydroxy-3,5-dimethoxybenzoicacidethylc Singoserp Novoserpina Syringic acid ethyl cbonate ester with methyl reserpate (1S,2R,3R,4aS,13bR,14aS)-3-(4-cbethoxyoxy-3,5-dimethoxy-benzoyl)oxy-2,11-dimethoxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquinolino[3,2-a] Yohimban-16-cboxylic acid, 18-[[4-[(ethoxycbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxy-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha Yohimban-16-cboxylic acid, 18-[[4-[(ethoxycbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxy-, methyl ester, (3b,16b,17a,18b,20a)- (9CI) Neoreserpan Methyl 18-((4-[(ethoxycbonyl)oxy]-3,5-dimethoxybenzoyl)oxy)-11,17-dimethoxyyohimban-16-cboxylate Raunova Syringopine 3b,20a-Yohimban-16b-cboxylic acid, 18b-hydroxy-11,17a-dimethoxy-, methyl ester, 4-hydroxy-3,5-dimethoxybenzoate (ester) ethyl cbonate (ester) (8CI) Revelox-Wirkstoff EINECS 201-527-0 HF-41T Ipores Reserpine Impurity 10 Isotens syrosingopine methyeserpateesterofsyringicacidethylcbonate Isotense SYROSINGOPINE(RG) Siroshuten Methyl 18beta-hydroxy-11,17alpha-dimethoxy-3beta,20alpha-yohimban-16beta-cboxylate 4-hydroxy Siringone

Description	Syrosingopine (Su 3118) is an antihypertensive agent. Syrosingopine can decrease brain dopamine levels[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Syrosingopine sensitizes cancer cells to killing by metformin[1].
References	[1]. Benjamin D, et al. Syrosingopine sensitizes cancer cells to killing by metformin. Sci Adv. 2016 Dec 23;2(12):e1601756. [2]. Furukawa T, et al. Selective depleting effect of syrosingopine on brain catecholamine levels with relation to morphine analgesia in the rat. Pharmacol Biochem Behav. 1976 Apr;4(4):419-25.

Density	1.35g/cm3
Boiling Point	795ºC at 760 mmHg
Melting Point	175ºC
Molecular Formula	C₃₅H₄₂N₂O₁₁
Molecular Weight	666.71500
Flash Point	434.6ºC
Exact Mass	666.27900
PSA	144.08000
LogP	4.63570
Index of Refraction	1.615
Water Solubility	Insuluble (3.1E-4 g/L) (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZG0175000

CHEMICAL NAME :: 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester, ester with 4-hydroxy-3,5-dimethoxybenzoic acid ethyl carbonate

CAS REGISTRY NUMBER :: 84-36-6

LAST UPDATED :: 199610

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C35-H42-N2-O11

MOLECULAR WEIGHT :: 666.79

WISWESSER LINE NOTATION :: T F6 D5 C666 EM ON&&TTTJ HO1 SOVR CO1 EO1 DOVO2& TO1 UVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,386,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 286 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,365,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 6,386,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 119,245,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1293 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,365,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 101 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,365,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 281 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,365,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 78,225,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 10 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 83,1405,1962

Hazard Codes	Xn
RIDADR	UN 1544
Packaging Group	III
Hazard Class	6.1(b)

18780-68-2

2901-66-8

84-36-6

Literature: US2813871 , ;

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