20324-87-2

• 常用中文名：6,6'-(1,3-亚脲基)双(1-萘酚-3-磺酸钠)
• 常用英文名：AMI 1
• CAS号：20324-87-2
• 分子式：C₂₁H₁₄N₂Na₂O₉S₂
• 分子量：548.453
• 相关类别： 信号通路 表观遗传学 组蛋白甲基转移酶
• 发布时间：2018-09-27 18:57:49
• 更新时间：2026-07-01 19:00:03
• AMI-1是一种有效的细胞渗透性的蛋白精氨酸N-甲基转移酶 (PRMTs) 抑制, 抑制人PRMT1 (IC50 =8.8μM) 和酵母Hmt1p (IC50 =3.0μm) 。

名称

• 中文名: 猩红酸钠盐
• 英文名: Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
• 中文别名: 7,7'-(羰基双(氮杂二基))双(4-羟基萘-2-磺酸钠); 猩红酸钠; AMI 1,蛋白GININE METHYLTRANSFERASE抑制剂; AMI 1,可逆蛋白精氨酸甲基转移酶抑制剂; 猩红酸钠 猩红酸钠盐 偶氮类染料
• 英文别名: AMI-1 disodium salt; Disodium 4-hydroxy-7-{[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoyl]amino}naphthalene-2-sulfonate; Disodium 7,7'-(Cbonyldiimino)Bis(4-Hydroxynaphthalené-2-Sulphonate); disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)cbamoylamino]naphthalene-2-sulfonate; Disodium 7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonate); AMI-1;AMI 1;AMI1; AMI-1 - AMI-1 sodium salt; AMI 1, protein ginine methyltransferase inhibitor; Disodium 7,7'-(cbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate); 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)cbamoylamino]naphthalene-2-sulfonate; J acid urea,disodiuM salt; AMI-1, 10 mM in DMSO; Dinatrium-7,7'-(cbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat); 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, sodium salt (1:2); SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE; Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate); Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate]; 7,7'-(cbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt; disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)cbamoylamino]naphthalene-2-sulfonate; AMI-1; Sodium 7,7'-(cbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate); protein ginine N-methyltransferases,AMI 1,Hmt1p,Inhibitor,AMI-1,inhibit,PRMT1,yeast-Hmt1p,AMI1,Histone Methyltransferase,PRMTs; disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)cbamoylamino]naphthalene-2-sulfonate

物化性质

• 分子式: C₂₁H₁₄N₂Na₂O₉S₂
• 分子量: 548.453
• 精确质量: 547.993591
• PSA: 212.75000
• LogP: 5.16400
• 外观性状: 粉末
• 储存条件: -20℃

生物活性

• 描述: AMI-1是一种有效的细胞渗透性的蛋白精氨酸N-甲基转移酶 (PRMTs) 抑制, 抑制人PRMT1 (IC50 =8.8μM) 和酵母Hmt1p (IC50 =3.0μm) 。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Sun Q, et al. PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation. J Immunol. 2015 Jul 1;195(1):298-306.

  [2]. Castellano S, et al. Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 1;5(3):398-414.

  [3]. Lv L, et al. PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells. Endocrine. 2015 Aug;49(3):669-682.

  [4]. Wang J, et al. Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation. J Med Chem. 2012 Sep 27;55(18):7978-7987.

安全

• 海关编码: 2924299090

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%