2557-49-5

• 常用中文名：二氟拉松
• 常用英文名：Diflorasone
• CAS号：2557-49-5
• 分子式：C₂₂H₂₈F₂O₅
• 分子量：410.452
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-08-01 19:11:00
• 更新时间：2026-07-13 18:24:38
• Diflorasone 是一种有效的局部抗炎类固醇。

名称

• 中文名: 二氟拉松
• 英文名: diflorasone
• 中文别名: 二氟拉松:双氟拉松; 双氟拉松; 氟替卡松丙酸酯杂质37、二氟拉松; Diflorasone :双氟拉松; 二氟拉松,10 MM DMSO 溶液; 二氟拉松 标准品; (6S,8S,10S,11S,13S,14S,16S,17R)-6,9-二氟-11,17-二羟基-17-(2-羟基乙酰基)-10,13,16-三甲基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[A]菲-3-酮; 地弗拉松
• 英文别名: (6a,11b,16b)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; Diflorasone, 10 mM in DMSO; (6S,8S,9S,10S,11S,13S,14S,16S,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; 6a,9a-Difluoro-16b-methyl-d-1,4-pregnadiene-11b,17a,21-triol-3,20-dione; (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; Fluticasone Propionate Impurity 28; (6α,11β,16β)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; diflorasonum [INN_la]; flumetasone; DIFLORASONE; (6S,8S,10S,11S,13S,14S,16S,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; Difloasone; 11β,17α,21-trihydroxy-6α,9α-difluoro-16β-methylpregna-1,4-diene-3,20-dione; (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; 6a,9a-Difluoro-16b-methylprednisolone; Diflorasone [INN:BAN]; (6α,11β,16β)-6,9-Difluoro-11,17,21-trihydroxy-16-Methyl-pregna-1,4-diene-3,20-dione; flumethasone; Diflorasone //BP; (6s,8s,9s,10s,11s,13s,14s,16s,17r)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; Fluticasone propionate impurity 37、 Diflorasone; Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16β)

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 569.8±50.0 °C at 760 mmHg
• 熔点: 228-239ºC
• 分子式: C₂₂H₂₈F₂O₅
• 分子量: 410.452
• 闪点: 298.4±30.1 °C
• 精确质量: 410.190491
• PSA: 94.83000
• LogP: 1.61
• 外观性状: 一种白色至粉红色结晶
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.579
• 储存条件: Refrigerator

生物活性

• 描述: Diflorasone 是一种有效的局部抗炎类固醇。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Wickrema Sinha AJ, et al. Percutaneous absorption and excretion of tritium-labeled diflorasone diacetate, a new topical corticosteroid in the rat, monkey and man. J Invest Dermatol. 1978 Dec;71(6):372-7.

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• 海关编码: 2937229000

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