65429-42-7

• 常用中文名：6Α,9Α-二氟-11Β-羟基-16Α-甲基-3-氧代-17Α-(丙酰氧基)雄甾-1,4-二烯-17 Β-羧酸
• 常用英文名：(6A,11B,16A,17A)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID
• CAS号：65429-42-7
• 分子式：C₂₄H₃₀F₂O₆
• 分子量：452.48800
• 发布时间：2019-01-08 20:28:00
• 更新时间：2026-08-02 15:41:29

名称

• 中文名: (6a,11b,16a,17a)-6,9-二氟-11-羟基-16-甲基-3-氧代-17-(丙酰氧基)雄甾-1,4-二烯-17-羧酸
• 英文名: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid
• 中文别名: 氟替卡松欧洲药典杂质A; 氟氟替卡松杂质A; (6A,11B,16A,17A)-6,9-二氟-11-羟基-16-甲基-3-氧代-17-(丙酰氧基)雄甾-1,4-二烯-17-羧酸; 丙酸氟替卡松杂质03; 氟替卡松丙酸酯杂质A; 6Α,9Α-二氟-11Β-羟基-16Α-甲基-3-氧代-17Α-(1-丙酸基)雄甾-1,4-二烯-17Β-甲酸; 氟替卡松 17Β-羧酸丙酸酯; 17Β羧酸丙酸氟替卡; 氟替卡松中间体 FT2; (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-(丙酰氧基)-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊基[A]菲-17-羧酸 (丙酸氟替卡松杂质); 氟替卡松17Β-羧酸丙酸酯; 丙酸氟替卡松杂质A2; 丙酸氟替卡松A; FLUTICASONE 17尾-CBOXYLIC ACID PROPIONATE; 氟替卡松丙酸酯杂质1; 氟替卡松杂质A; 氟替卡松杂质1(氟替卡松杂质A); 6Α,9Α-二氟-11Β-羟基-16Α-甲基-3-氧代-17Α-(1-氧代丙氧基)雄甾-1,4-二烯-17Β-甲酸; 氟替卡松17Β-羧酸丙酸; 丙酸氟替卡松杂质A
• 英文别名: Fluticasone 17β-Cboxylic Acid Propionate; Fluticasone Propionate Impurity A/Fluticasone Cboxylic Acid Propionate/6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxo-17-(propanoyloxy) androsta-1,4-diene-17β-cboxylic acid; Androsta-1,4-diene-17- cboxylic acid, 6,9-difluoro-11- hydroxy-16-Methyl-3-oxo-17-(1-oxopropoxy)-,(6α,11β,16α,17α); 6α,9α- Difluoro-11 β- Hydroxy-16 α- Methyl-3-oxo-17 α- (1-propionyl) androsterol-1,4-diene-17 β- formic acid; 6alpha,9-Difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-(propanoyloxy)androsta-1,4-diene-17beta-c; Fluticasone Imp A; (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-cboxylic Acid; 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)androsta-1,4-diene-17β-cboxylic acid; UNII-TP537C010A; Flutione 17|A-Carboxylic Acid Propionate; Fluticasone Impurity A (Fluticasone Cboxylic Acid Propionate); 6a,9a-difluoro-l1~-hydroxy-l6a-methyl-l7apropionyloxy-3-oxoandrosta-l,4-diene-l7~-cboxyliacc id; 6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-cboxylic acid; 6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxo-17-(propanoyloxy) androsta-1,4-diene-17β-cboxylic acid; Fluticasone Impurity 1(Fluticasone Impurity A); (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propio (Fluticasone Propionate Impurity); Fluticasone IMpurity A; (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17; (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxo-propoxy)androsta-1,4-diene-17-cboxylic acid; Fluticasone Propinate impurity A -I; Fluticasone Propionate Impurity; fluticasone propionate impurity -ZA; "6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxo-17- (propanoyloxy)androsta-14-diene-17β-cboxylic acid; 6α, 9α-Difluoro-11β-Hydroxy-16α-methyl-3-oxo-17α-(1-oxopropyloxy) androstene-1,4-diene-17β-formic acid; 6alpha,9-Difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-(propanoyloxy)androsta-1,4-diene-17beta-cboxylic Acid; Fluticasone Propionate Impurity A; Flutione propionate-17beta-carboxylic acid; BNKY011-FP02; FLUTICASONE PROPIONATE, 17-BETA CBOXYLIC ACID; (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-cboxylic acid; (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-cboxylic acid; Fluticasone Propinate impurity A; Fluticasone 17beta-Cboxylic Acid Propionate; Flutione 17beta-carboxylic acid

物化性质

• 密度: 1.33
• 沸点: 577.645ºC at 760 mmHg
• 分子式: C₂₄H₃₀F₂O₆
• 分子量: 452.48800
• 闪点: 303.149ºC
• 精确质量: 452.20100
• PSA: 100.90000
• LogP: 3.32780
• 折射率: 1.561
• 储存条件: -20°C

合成路线

79-03-8 28416-82-2 ~97% 65429-42-7

文献：Alpharma APS Patent: EP1466920 A1, 2004 ; Location in patent: Page 7 ;

123-62-6 28416-82-2 ~99% 65429-42-7

文献：SUN PHARMACEUTICAL INDUSTRIES LIMITED Patent: US2005/256325 A1, 2005 ; Location in patent: Page/Page column 8 ;

79-03-8 109-89-7 96-22-0 28416-82-2 78-93-3 详细

文献：Barkalow, Jufang; Chamberlin, Steven A.; Cooper, Arthur J.; Hossain, Azad; Hufnagel, John J.; Langridge, Denton Patent: US2002/133032 A1, 2002 ;

2557-49-5 ~% 65429-42-7

文献：Journal of Organic Chemistry, , vol. 51, # 12 p. 2315 - 2328

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