78964-85-9

• 常用中文名：磷霉素氨丁三醇
• 常用英文名：Fosfomycin tromethamine
• CAS号：78964-85-9
• 分子式：C₇H₁₈NO₇P
• 分子量：259.194
• 相关类别： 原料药 抗生素类药物 其它抗生素类药
• 发布时间：2018-04-11 08:00:00
• 更新时间：2026-07-10 17:40:22
• Fosfomycin tromethamine (MK-0955 tromethamine) 是一种能透过血脑屏障的广谱抗生素,不可逆地抑制细胞壁合成的早期阶段。Fosfomycin tromethamine 对多种细菌具有杀菌活性,这些细菌包括耐多药 (MDR),广泛耐药 (XDR) 和耐全药 (PDR) 细菌。

名称

• 中文名: 复美欣氨基丁三醇
• 英文名: Fosfomycin tromethamine
• 中文别名: 2-氨基-2-(羟甲基)丙烷-1,3-二醇((2R,3S)-3-甲基环氧乙烷-2-基)膦酸酯; Fosfomycin Tromethamine 磷霉素氨基丁三醇；复美欣氨基丁三醇；复安欣; (-)-(1R,2S)-1,2-环氧丙基膦酸氨基丁三醇; 磷霉素缓血酸铵; 磷霉素氨丁三醇NA; Fosfomycin Tromethamine 磷霉素氨基丁三醇; 磷霉素氨丁三醇对照品; 复美欣氨基丁三醇 标准品; 磷霉素三甲胺; 磷霉素氨丁三醇/复美欣氨基丁三醇; 磷霉素氨丁三醇/fosfomycin trometamol; 复安欣; 2 - 氨基-2-(羟甲基)丙烷-1,3-二醇((2R,3S)-3-甲基环氧乙烷-2-基)膦酸酯 (磷霉素杂质); 磷霉素氨基丁三醇
• 英文别名: acide [(2R,3S)-3-méthyloxiran-2-yl]phosphonique - 2-amino-2-(hydroxyméthyl)propane-1,3-diol (1:1); [(2R,3S)-3-Methyloxiran-2-yl]phosphonsäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1); Fosfomycin Trometamol Impurity 13; methyl)-1,3-propanediol(1:1); Fosfomycin Tromethaminel; Fosfomycin trometamol CRS; Fosfomycin Tromethamine; Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); fosfomycintrometamolsalt; Fosfomycin tromethanol; Tromethamine fosfosmycin; tromethamine-fosfomycin; fosfomycincompd.withtrometamol; (1R,2S)-(1,2-oxypropyl)phosphonic acid, compound with 2-amino-2-(hyd roxymethyl)-1,3-propanediol (1:1); (1R,2S)-(1,2-Epoxypropyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1); z1282; Fosfomycin Tromethamine 2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3- methyloxiran-2-yl) phosphonate; mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate; 2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate; phosphomycin trometamol; Fosfomycin trometamol; Fosfomycine Trometamol; (2R-cis)-(3-Methyloxiranyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)propane-1,3-diol (1:1); (3-methyloxiranyl)-phosphonicaci(2r-cis)-phosphonicacicompd.with2-amino-2-(hydroxy; FosfoMycin troMethaMine API; Fosfomycin tromethamine //BP; Fosfomycin TrometamolQ: What is Fosfomycin Trometamol Q: What is the CAS Number of Fosfomycin Trometamol Q: What is the storage condition of Fosfomycin Trometamol Q: What e the applications of Fosfomycin Trometamol; 2-Amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate (Fosfomycin Impurity); Fosfomycin tramine; [(2R,3S)-3-Methyl-2-oxiranyl]phosphonic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); (2r-cis)-(3-methyloxiranyl)phosphonic acid compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1); FOSFOMYCIN TROMETHAMOL; Fosfomycin tromethamine (MK-0955 tromethamine); monuril; FOSFOMYCIN TROMETAMOL; 2-Amino-2-(hydroxymethyl)-propan-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate; [(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1); 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium hydrogen [(2R,3S)-3-methyloxiran-2-yl]phosphonate

物化性质

• 沸点: 357ºC at 760 mmHg
• 分子式: C₇H₁₈NO₇P
• 分子量: 259.194
• 闪点: 169.7ºC
• 精确质量: 259.082092
• PSA: 166.58000
• 外观性状: 白色或灰白色粉末
• 储存条件: 2-8°C，避光
• 水溶解性: Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.

生物活性

• 描述: Fosfomycin tromethamine (MK-0955 tromethamine) 是一种能透过血脑屏障的广谱抗生素,不可逆地抑制细胞壁合成的早期阶段。Fosfomycin tromethamine 对多种细菌具有杀菌活性,这些细菌包括耐多药 (MDR),广泛耐药 (XDR) 和耐全药 (PDR) 细菌。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel). 2017 Oct 31;6(4). pii: E24.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SZ9570000 CAS REGISTRY NUMBER : 78964-85-9 LAST UPDATED : 199403 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C4-H11-N-O3.C3-H7-O4-P MOLECULAR WEIGHT : 259.23 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988

安全

• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport

合成路线

855392-18-6 26016-99-9 ~% 78964-85-9

文献：EP1762573 A1, ; Page/Page column 2 ;

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