6042-32-6

• 常用中文名：Taurolithocholic Acid sodium salt
• 常用英文名：TAUROLITHOCHOLIC ACID SODIUM SALT
• CAS号：6042-32-6
• 分子式：C₂₆H₄₄NNaO₅S
• 分子量：505.68600
• 相关类别： 信号通路 跨膜转运 钙通道
• 发布时间：2018-02-22 08:00:00
• 更新时间：2024-01-04 18:33:49
• 牛磺胆酸钠盐是一种有效的胆汁抑制剂,是一种有效的钙离子激动剂[1]。

名称

• 中文名: 牛磺石胆酸钠盐
• 英文名: taurolithocholic acid sodium salt
• 中文别名: 牛磺石胆酸钠(进分); 牛磺石胆酸钠
• 英文别名: sodium taurolithocholic acid; N-(3a-Hydroxy-5-cholan-24-oyl)taurine Monosodium Salt; sodium taurolithocholate; SODIUM TAUROLITHOCHOLATE SODIUM SALT; 5BETA-CHOLANIC ACID-3ALPHA-OL 24-N-(2-SULFOETHYL)AMIDE SODIUM; taurolithocholic acid sodium; TAUROLITHIOCHOLIC ACID SODIUM

物化性质

• 分子式: C₂₆H₄₄NNaO₅S
• 分子量: 505.68600
• 精确质量: 505.28400
• PSA: 114.91000
• LogP: 5.55560
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: 牛磺胆酸钠盐是一种有效的胆汁抑制剂,是一种有效的钙离子激动剂[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 代谢疾病
• 体外研究: 低浓度(5µM)的牛磺胆酸(TLCA)倾向于选择性地将PKC e-亚型的膜相关部分增加44.1%±40.2%[1]。TLCA(10µM)选择性诱导PKCε-亚型移位到肝细胞膜,这是激活可移动PKC亚型的关键步骤[1]。
• 体内研究: 牛磺胆酸(TLCA)通过PI3K依赖机制在灌流大鼠肝脏和大鼠肝细胞偶联物中发挥胆汁抑制作用[2]。
• 参考文献:

  [1]. U Beuers, et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology. 1999 Feb;29(2):477-82.

  [2]. Ulrich Beuers, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem. 2003 May 16;278(20):17810-8.

MSDS

Section 1. Chemical Product and Company Identification Taurolithocholic acid sodium salt Common Name/ Trade Name Taurolithocholic acid sodium salt Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Some metallic oxides. Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. As with most organic solids, fire is possible at elevated temperatures Special Remarks on Fire Hazards Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust Hazardsexplosion hazard. Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Taurolithocholic acid sodium salt Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not breathe dust. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.)OdorNot available. TasteNot available. Molecular Weight505.7 g/mole ColorOff-white. pH (1% soln/water)Not available. Boiling PointNot available. Melting PointNot available. Critical TemperatureNot available. Not available. Specific Gravity Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Not available. Water/Oil Dist. Coeff. Ionicity (in Water)Not available. See solubility in water, methanol. Dispersion Properties SolubilityPartially soluble in methanol. Solubility in Methanol: 50 mg/ml Section 10. Stability and Reactivity Data StabilityThe product is stable. Instability TemperatureNot available. Conditions of InstabilityExcess heat Incompatibility with variousNot available. substances CorrosivityNot available. Taurolithocholic acid sodium salt Not available. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans May cause damage to the following organs: liver. Other Toxic Effects on Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: Dust may cause eye irritation. Inhalation: Dust may cause respiratory tract irritation. Ingestion: Expected to be a low hazard. Chronic Potential Health Effects: Ingestion: Prolonged or repeated ingestion may affect the liver. Symptoms may include prompt deimution of bile flow, hyperbilirubinemia, cholestasis, impaired canalicular membrane function and intracanalicular precipitation. Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe product itself and its products of degradation are not toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. Identification Not applicable. Special Provisions for Transport Taurolithocholic acid sodium salt DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)This product is not classified according Not applicable. to the EU regulations. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Taurolithocholic acid sodium salt SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport