Taurolithocholic Acid sodium salt结构式
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常用名 | Taurolithocholic Acid sodium salt | 英文名 | TAUROLITHOCHOLIC ACID SODIUM SALT |
|---|---|---|---|---|
| CAS号 | 6042-32-6 | 分子量 | 505.68600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C26H44NNaO5S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
Taurolithocholic Acid sodium salt用途牛磺胆酸钠盐是一种有效的胆汁抑制剂,是一种有效的钙离子激动剂[1]。 |
| 中文名 | 牛磺石胆酸钠盐 |
|---|---|
| 英文名 | taurolithocholic acid sodium salt |
| 中文别名 | 牛磺石胆酸钠(进分) | 牛磺石胆酸钠 |
| 英文别名 | 更多 |
| 描述 | 牛磺胆酸钠盐是一种有效的胆汁抑制剂,是一种有效的钙离子激动剂[1]。 |
|---|---|
| 相关类别 | |
| 体外研究 | 低浓度(5µM)的牛磺胆酸(TLCA)倾向于选择性地将PKC e-亚型的膜相关部分增加44.1%±40.2%[1]。TLCA(10µM)选择性诱导PKCε-亚型移位到肝细胞膜,这是激活可移动PKC亚型的关键步骤[1]。 |
| 体内研究 | 牛磺胆酸(TLCA)通过PI3K依赖机制在灌流大鼠肝脏和大鼠肝细胞偶联物中发挥胆汁抑制作用[2]。 |
| 参考文献 |
| 分子式 | C26H44NNaO5S |
|---|---|
| 分子量 | 505.68600 |
| 精确质量 | 505.28400 |
| PSA | 114.91000 |
| LogP | 5.55560 |
| 储存条件 | -20°C，密闭，干燥 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
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Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.
Arterioscler. Thromb. Vasc. Biol. 33(7) , 1663-9, (2013) TGR5 is a G-protein-coupled receptor for bile acids. So far, little is known about the function of TGR5 in vascular endothelial cells.In bovine aortic endothelial cells, treatment with a bile acid hav... |
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Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis.
PLoS ONE 7(12) , e52647, (2012) Angiotensin II (AT-II) is a pro-fibrotic compound that acts via membrane-bound receptors (AT-1R/AT-2R) and thereby activates hepatic stellate cells (HSCs). AT-II receptor blockers (ARBs) are thus impo... |
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Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.
J. Biol. Chem. 288(1) , 570-80, (2013) Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes pancreatic a... |
| sodium taurolithocholic acid |
| N-(3a-Hydroxy-5-cholan-24-oyl)taurine Monosodium Salt |
| sodium taurolithocholate |
| SODIUM TAUROLITHOCHOLATE SODIUM SALT |
| 5BETA-CHOLANIC ACID-3ALPHA-OL 24-N-(2-SULFOETHYL)AMIDE SODIUM |
| taurolithocholic acid sodium |
| TAUROLITHIOCHOLIC ACID SODIUM |
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