24237-54-5

• 常用中文名：2-氨基-6-苄基-4,5,6,7-四氢噻吩并[2,3-c]吡啶-3-甲酸乙酯
• 常用英文名：Tinoridine
• CAS号：24237-54-5
• 分子式：C₁₇H₂₀N₂O₂S
• 分子量：316.41800
• 相关类别： 原料药 解热镇痛药 非甾抗炎药
• 发布时间：2018-12-25 17:11:18
• 更新时间：2026-07-01 10:13:00
• 替诺瑞定(Y-3642)是一种口服活性非甾体抗炎剂,具有较强的抗氧化能力和自由基清除剂活性。替诺瑞定通过抑制COX酶发挥作用,参与肝毒性抑制。[1][2][3].

名称

• 中文名: 2-氨基-6-甲基-4,5,6,7-四噻吩[2,3-C]吡啶-3-甲酸乙酯
• 英文名: ethyl 2-amino-6-benzyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
• 中文别名: 2-氨基-6-苯基-4,5,6,7-四氢噻吩[2,3-C]吡啶-3-羧酸乙酯; 氨苄噻吡酯; 替诺立定; 噻嗯吡啶; 2-氨基-6-苄基-4,5,6,7-四氢噻吩并[2,3-C]吡啶-3-羧酸乙酯; 2-氨基-6-苄基-4,5,6,7-四氢噻吩乙酯[2,3-c]吡啶-3-羧酸乙酯; 替诺立定,10 MM DMSO 溶液
• 英文别名: Tinoridine, 10 mM in DMSO; tinoridine; 2-amino-3-aethoxycbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridin; Dimaten; Cholecalciferol Impurity 26; 2-amino-3-ethoxycbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine; Thieno[2,3-c]pyridine-3-cboxylic acid, 2-amino-4,5,6,7-tetrahydro-6-(phenylMethyl)-, ethyl ester; Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-cboxylate; Tinoridine //BP; Nonflamin (free base); Thieno(2,3-c)pyridine-3-cboxylic acid, 2-amin; ethyl 2-amino-6-(phenylmethyl)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-cboxylate; Thieno(2,3-c)pyridine-3-cboxylic acid, 2-amino-4,5,6,7-tetrahydro-6-(phenylmethyl)-, ethyl ester (9CI); 3-c)pyridine-3-cboxylicacid,4,5,6,7-tetrahydro-2-amino-6-benzyl-thieno(; 2-AMINO-3-ETHOXY-carbonyl-6-BENZYL-4,5,6,7-TETRAHYDROTHIEN; 2-amino-6-(phenylmethyl)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-cboxylic acid ethyl ester; 2-amino-6-(phenylmethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-ium-3-cboxylic acid ethyl ester; ethyl 2-amino-6-benzyl-4H; 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine-3-cboxylicacidet; 2-Amino-6-benzyl-3-(ethoxycbonyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine, Tinoridine; ethyl 2-amino-6-benzyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-cboxylate; 2-Amino-6-benzyl-4,5,6,7-tetrahydro-thieno<pyridin-3-carbonsaeuereethylester; 2-amino-6-(benzyl)-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-cboxylic acid ethyl ester; Y 3642; 7H-thieno[2; y-3642

物化性质

• 密度: 1.256 g/cm3
• 沸点: 493.5ºC at 760 mmHg
• 熔点: 112-113ºC
• 分子式: C₁₇H₂₀N₂O₂S
• 分子量: 316.41800
• 精确质量: 316.12500
• PSA: 83.80000
• LogP: 3.58440
• 蒸汽压: 7E-10mmHg at 25°C
• 储存条件: 室温

生物活性

• 描述: 替诺瑞定(Y-3642)是一种口服活性非甾体抗炎剂,具有较强的抗氧化能力和自由基清除剂活性。替诺瑞定通过抑制COX酶发挥作用,参与肝毒性抑制。[1][2][3].
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 体外研究: 替诺瑞定(10-100μM)对大鼠肝脏和肾脏溶酶体以及肝实质细胞的稳定性有影响[3]。替诺瑞定(1、10和100μM；30分钟)抑制体外肝赖氨酸自发释放酸性磷酸酶[3]。
• 体内研究: 替诺瑞定(100 mg/kg；口服；单剂量)可抑制大鼠的CCl4肝毒性,对CCl4诱导的酶活性有很强的控制作用[2]。替诺瑞定(100 mg/kg；i.p.；单剂量)在体内保护大鼠肝脏和肾脏溶酶体的稳定性[3]。动物模型：雄性Wistar大鼠(180-220 g)[2]剂量：100 mg/kg给药：口服灌胃；单剂量；结果：抑制了CCl4诱导的血清谷氨酸-草酰乙酸转氨酶和谷氨酸-丙酮酸转氨酶活性的升高,并挽救了肝微粒体细胞色素p-450和葡萄糖-6-磷酸酶活性。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XJ9088300 CHEMICAL NAME : Thieno(2,3-c)pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-2-amino-6-benzyl-, ethyl ester CAS REGISTRY NUMBER : 24237-54-5 LAST UPDATED : 199706 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C17-H20-N2-O2-S MOLECULAR WEIGHT : 316.45 WISWESSER LINE NOTATION : T56 BS HN&TJ CZ DVO2 H1R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,998,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,998,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,998,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,998,1970

安全

• 海关编码: 2934999090

合成路线

3612-20-2 105-56-6 ~92% 24237-54-5

文献：Meng, Shuangming; Jia, Zhifang; Wang, Kewei; Fan, Yueqin; Guo, Yong Synthetic Communications, 2014 , vol. 44, # 10 p. 1461 - 1465

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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%