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148-18-5生产厂家

148-18-5价格

相关CAS号：
148-18-5 31999-88-9
6509-22-4 563-17-7
54091-78-0 29973-13-5
563-12-2 3006-10-8
352-93-2 55860-53-2
1158522-08-7 2147960-29-8
940364-43-2 134104-43-1
131615-57-1 6906-52-1
930439-75-1 1018584-77-4
2229153-36-8 1375289-11-4

148-18-5

148-18-5结构式
148-18-5结构式
  • 常用中文名：乙硫氮
  • 常用英文名：Sodium diethyldithiocarbamate
  • CAS号：148-18-5
  • 分子式：C5H10NNaS2
  • 分子量：171.259
  • 相关类别： 有机原料 有机金属盐
  • 发布时间：2018-02-04 08:00:00
  • 更新时间：2024-01-02 12:31:06
  • Ditiocarb sodium (Sodium diethyldithiocarbamate) 是一种铜试剂,与 Cu2+ 溶液反应,生成络合物,提高了铜置换沉淀速率。Sodium diethyldithiocarbamate 可降低 HIV 感染。

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中文名 二乙基二硫代氨基甲酸钠
英文名 Sodium diethyldithiocarbamate
中文别名 乙硫氮
DDTC钠盐
二硫卡钠
二乙胺荒酸钠
英文别名 EINECS 205-710-6
sodium,N,N-diethylcarbamodithioate
Diethyldithiocarbamic acid sodium salt
MFCD00041028
描述 Ditiocarb sodium (Sodium diethyldithiocarbamate) 是一种铜试剂,与 Cu2+ 溶液反应,生成络合物,提高了铜置换沉淀速率。Sodium diethyldithiocarbamate 可降低 HIV 感染。
相关类别
靶点

HIV[2]

体外研究 Ditiocarb sodium(二乙基二硫代氨基甲酸钠)与Cu2 +溶液反应,得到二乙基二硫代氨基甲酸铜络合物,提高了胶结速率[1]。 Ditiocarb sodium是一种具有很强抗氧化能力和螯合活性的药物[2]。
体内研究 Ditiocarb sodium(二乙基二硫代氨基甲酸钠)可改善新生和老年小鼠的抑制免疫反应。二乙基二硫代氨基甲酸钠在不降低抗肿瘤活性的情况下防止动物中的顺铂肾毒性。在艾滋病模型中,Ditiocarb钠可以减少淋巴结病和高球蛋白血症,恢复免疫能力,延长生存期[2]。
参考文献

[1]. Abeer A.El-Saharty, et al. Sodium diethyldithiocarbamate as accelerator of the rate of copper cementation. The Egyptian Journal of Aquatic Research. 2015 Dec, Volume 41(4):289-293.

[2]. Hersh EM, et al. Ditiocarb sodium (diethyldithiocarbamate) therapy in patients with symptomatic HIV infection and AIDS. A randomized, double-blind, placebo-controlled, multicenter study. JAMA. 1991 Mar 27;265(12):1538-44.
密度 1.086g/cm3
沸点 176.4ºC at 760mmHg
熔点 95°C
分子式 C5H10NNaS2
分子量 171.259
闪点 60.5ºC
精确质量 171.015228
PSA 60.63000
LogP 1.81060
外观性状 无气味的白色或略棕色或略粉红色晶体
储存条件 室温
稳定性

遇酸分离出二硫化碳可使溶液浑浊。遇明火、高热可燃。其粉体与空气可形成爆炸性混合物，当达到一定
浓度时，遇火星会发生爆炸。受高热分解放出有毒的气体。

水溶解性 >=10 g/100 mL at 14 ºC
计算化学

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:2

5.互变异构体数量:无

6.拓扑分子极性表面积36.3

7.重原子数量:9

8.表面电荷:0

9.复杂度:83

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2
更多

1.性状：易溶于水，溶于乙醇，其溶液呈碱性。溶于甲醇、乙醇、丙酮，不溶于乙醚、苯。

2.熔点（ºC）：95
Name: Diethyldithiocarbamic acid sodium salt trihydrate Material Safety Data Sheet
Synonym: Sodium diethyldithiocarbamate trihydrate; Diethylcarbamodithioic acid sodium salt trihydrate; Dithiocarb trihydrate; DTC trihydrate; DDC trihydrate; DEDC trihydrate; DDTC trihydrate; DeDTC trihydrate; chelating agent with strong affinity for H
CAS: 148-18-5
Section 1 - Chemical Product MSDS Name:Diethyldithiocarbamic acid sodium salt trihydrate Material Safety Data Sheet
Synonym:Sodium diethyldithiocarbamate trihydrate; Diethylcarbamodithioic acid sodium salt trihydrate; Dithiocarb trihydrate; DTC trihydrate; DDC trihydrate; DEDC trihydrate; DDTC trihydrate; DeDTC trihydrate; chelating agent with strong affinity for H
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
148-18-5 Sodium diethyldithiocarbamate trihydra >99 unlisted
Hazard Symbols: XN
Risk Phrases: 22
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May be harmful if swallowed. Contact with stomach acid may liberate carbon disulfide which primarily affects the nervous, cardiovascular, and reproductive systems.
Inhalation:
Causes respiratory tract irritation.
Chronic:
May cause reproductive and fetal effects. Prolonged or repeated exposure affects the nervous system.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store protected from moisture. Refrigeration has been recommended.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 148-18-5: Germany: 2 mg/m3 TWA (inhalable fraction) Netherlands: 2 mg/m3 MAC CAS# 20624-25-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: very slightly yellow
Odor: Not available.
pH: 11.6 (10% aq soln)
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 95-98.5 deg C
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: C5H10NNaS2.3H2O
Molecular Weight: 225.31
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 148-18-5: EZ6475000 CAS# 20624-25-3: EZ6550000 LD50/LC50:
CAS# 148-18-5: Oral, mouse: LD50 = 1500 mg/kg; Oral, rabbit: LD50 = 500 mg/kg; Oral, rat: LD50 = 1500 mg/kg; Skin, rat: LD50 = >1 gm/kg.
CAS# 20624-25-3: Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 1500 mg/kg.
Carcinogenicity:
Sodium diethyldithiocarbamate, anhydrous - Not listed by ACGIH, IARC, or NTP.
Sodium diethyldithiocarbamate trihydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 148-18-5: 3
CAS# 20624-25-3: 2
Canada
CAS# 148-18-5 is listed on Canada's DSL List.
CAS# 148-18-5 is not listed on Canada's Ingredient Disclosure List.
CAS# 20624-25-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 148-18-5 is listed on the TSCA inventory.
CAS# 20624-25-3 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).

SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

急性毒性LD50大鼠，小鼠(mg/kg)：2830，1870口服；小鼠：＞1000静脉注射。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EZ6475000
CHEMICAL NAME :
Carbamic acid, diethyldithio-, sodium salt
CAS REGISTRY NUMBER :
148-18-5
LAST UPDATED :
199710
DATA ITEMS CITED :
34
MOLECULAR FORMULA :
C5-H10-N-S2.Na
MOLECULAR WEIGHT :
171.27
WISWESSER LINE NOTATION :
SUYSHN2&2 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1032 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7 gm/kg/7D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Endocrine - changes in thymus weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
9900 mg/kg/30D-I
TOXIC EFFECTS :
Behavioral - ataxia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
76 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
2100 mg/kg
SEX/DURATION :
male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Endocrine - androgenic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1935 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1935 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
100 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
50 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
1500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,155,1988 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,217,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,217,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 12,601,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84765 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 732 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84765 No. of Facilities: 445 (estimated) No. of Industries: 17 No. of Occupations: 16 No. of Employees: 7970 (estimated) No. of Female Employees: 1982 (estimated)

危害码 (欧洲) Xi
WGK德国 1
海关编码 2930909090

将二乙醇胺溶于甲醇中，加入二硫化碳的甲醇溶液，滴入40%的氢氧化钠甲醇溶液，滤出析出的结晶，用甲醇洗3～4次，再用甲醇重结晶，干燥，得纯品二乙基二硫代氨基甲酸钠。

海关编码 2930909090
中文概述 2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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