149198-47-0

• 常用中文名：(3R,4S)-3-(三乙基硅氧基)-4-苯基-2-氧-氮杂环丁-1-甲酸叔丁酯
• 常用英文名：(3R,4S)-tert-Butyl 2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate
• CAS号：149198-47-0
• 分子式：C₂₀H₃₁NO₄Si
• 分子量：377.550
• 发布时间：2018-12-30 18:56:46
• 更新时间：2026-09-12 12:02:49

名称

• 中文名: (3R,4S)-3-(三乙基硅氧基)-4-苯基-2-氧-氮杂环丁-1-甲酸叔丁酯
• 英文名: (3R,4S)-1-t-Boc-3-[(triethylsilyl)oxy]-4-phenyl-2-azatidinone
• 中文别名: (3R,4S)-叔丁基-2-氧代-4-苯基-3-(三乙基甲硅烷)氮杂环丁烷-1-甲酸叔丁酯; (3R,4S)-2-氧代-4-苯基-3-[(三乙基硅基)氧]氮杂环丁烷-1-羧酸叔丁酯 多西侧链; 多西四元环/(3R,4S)-3-(三乙基硅氧基)-4-苯基-2-氧-氮杂环丁-1-甲酸叔丁酯; 多西四元环; (3R,4S)-叔丁基 2-氧代-4-苯基-3-(三乙基硅氧基)氮杂环丁-1-羧酸酯; (3R,4S)2-氧代-4-苯基-3-((三乙基硅烷基)氧)氮杂环丁烷-1-羧酸叔丁酯; (3R,4S)-2-氧代-4-苯基-3-[(三乙基硅基)氧]氮杂环丁烷-1-羧酸叔; (3R,4S)-1-叔丁氧基羰基-3-三乙基硅氧基-4-苯基-2- 丙内酰胺; 多西他塞侧链; 多烯紫杉醇的中间体四元环侧链; (3R,4S)-1-叔丁氧羰基-3-三乙基硅氧基-4-苯基-2-氮杂环丁酮; (3R,4S)-1-叔丁氧基羰基-3-三乙基硅氧基-4-苯基-2-丙内酰胺; 多西侧链(3R,4S)-TERT-BUTYL 2-OXO-4-PHENYL-3-(TRIETHYLSILYLOXY)AZETIDINE-1-CBOXYLATE; TERT-BUTYL (3R,4S)-2-OXO-4-PHENYL-3-[(TRIETHYLSILYL)OXY]AZETIDINE-1-CBOXYLATE (3R,4S)-2-氧代-4-苯基-3-[(三乙基硅基)氧]氮杂环丁烷-1-羧酸叔丁酯; N-叔丁氧羰基-3-(三乙基硅基)-4-苯基-2-吖叮啶酮; (3R,4S)-2-氧代-4-苯基-3-[(三乙基硅基)氧]氮杂环丁烷-1-羧酸叔丁酯; (3R,4S)-3-(三乙基硅氧基)-4-苯基-2-氧-氮杂环丁-1-甲酸叔丁酯,多烯紫杉醇侧链; 多西四元环/(3R,4S)-3-(三乙基硅氧基)-4-苯基-2-氧-氮杂环丁-10-甲酸叔丁酯
• 英文别名: tert-Butyl (3R,4S)-2-oxo-4-phenyl-3-[(triethylsilyl)oxy]azetidine-1-carboxylate; (3R,4S)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]-1-azetidinecboxylic acid 1,1-dimethylethyl ester; (3R,4S)-1-TERT-BUTOXYCBONYL-3-TRIETHYLSILYLOXY-4-PHENYL-2-AZETIDINONE; (3R,4S)-tert-Butyl 2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-cboxylate; (3R,4S)-3-triethylsilanyloxy-4-phenyl-N-Boc-2-azetidinone; (3R,4S)-1-t-Boc-3-[(triethylsilyl)oxy]-4-phenyl-2-azetidinone; (3r,4s)-1-Azetidine Cboxylic Acid-2-Oxo-4-Phenyl-3-[(Triethylsilyl)Oxy]-1,1-Dimethyl Ethyl Ester; (3R,4S)-1-t-butoxycbonyl-3-triethylsilyloxy-4-phenyl-2-azetidinone; (3R,4S)-1-Azetidinecboxylicacid-2-Oxo-4-Phenyl-3-[(Triethylsily)Oxy]-1,1-DimethylethylEsterCasNo; MFCD08273948; tert-butyl (3R,4S)-2-oxo-4-phenyl-3-triethylsilyloxyazetidine-1-carboxylate; (3R,4S)-tert-Butyl 2-oxo-4-phenyl-3-(triethylsilyloxy)azetid; (3R,4S)-1-AZETIDINECBOXYLIC ACID 2-OXO-4-PHENYL-3-[(TRIETHYLSILY)OXY]-1,1-DIMETHYLETHYL ESTER; 2-Methyl-2-propanyl (3R,4S)-2-oxo-4-phenyl-3-[(triethylsilyl)oxy]-1-azetidinecarboxylate; tert-Butyl (3R,4S)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]azetidine-1-cboxylate; 2-oxo-4-phenyl-3-triethylsilyloxy-1-azetidinecboxylic acid tert-butyl ester; (3R ,4S )-N -BOC-4-phenyl-3-(triethylsilyloxy)-azetidinone; (3R-cis)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]-1-azetidinecboxylic Acid 1,1-Dimethylethyl Ester; (3R, 4S) -3- (triethylsiloxy) -4-phenyl-2-oxo-azacyclobutan-1-cboxylate tert butyl ester; (3R,4S)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]azetidine-1-cboxylic Acid tert-Butyl Ester; (3R-cis)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]-1- azetidinecboxylic Acid 1,1-DiMethylethyl Es; 1-Azetidinecboxylic acid, 2-oxo-4-phenyl-3-[(triethylsilyl)oxy]-, 1,1-dimethylethyl ester, (3R,4S); (3R,4S)-1-Azetidinecboxylic; （3R,4S)-3triethylsilanyloxy-4-pheny-N-Boc-2-azetidinone; DOCETAXEL SIDE CHAIN NO 2

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 463.1±45.0 °C at 760 mmHg
• 分子式: C₂₀H₃₁NO₄Si
• 分子量: 377.550
• 闪点: 233.9±28.7 °C
• 精确质量: 377.202240
• PSA: 55.84000
• LogP: 4.38
• 外观性状: 液体;Colorless to Light yellow clear liquid
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.517
• 储存条件: <0°C;避免加热

安全

• 危害码 (欧洲): Xi

合成路线

24424-99-5 149140-54-5 ~87% 149198-47-0

文献：Paterson, Ian; Naylor, Guy J.; Fujita, Takeshi; Guzman, Esther; Wright, Amy E. Chemical Communications, 2010 , vol. 46, # 2 p. 261 - 263

288-32-4 17922-24-6 39994-75-7 ~% 149198-47-0

文献：US5350866 A1, ;

994-30-9 ~% 149198-47-0

文献：Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152

132127-34-5 ~% 149198-47-0

文献：Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152

132127-31-2 ~% 149198-47-0

文献：Tetrahedron Letters, , vol. 34, # 26 p. 4149 - 4152

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