1051375-10-0

• 常用中文名：卡替拉韦
• 常用英文名：Cabotegravir
• CAS号：1051375-10-0
• 分子式：C₁₉H₁₇F₂N₃O₅
• 分子量：405.352
• 相关类别： 生物化工 抑制剂 微生物学(Microbiology) Integrase 抑制剂
• 发布时间：2018-09-17 16:30:13
• 更新时间：2026-07-08 17:59:50
• Cabotegravir是一种有效的HIV整合酶抑制剂, 用于治疗和预防艾滋病毒感染, Cabotegravir抑制OAT1 (IC50为0.81 μM) 和OAT3 (IC50为0.41 μM)。

名称

• 中文名: 卡替拉韦
• 英文名: SureCN82803
• 中文别名: 卡博特韦,10 MM DMSO 溶液; 卡博特韦; 卡博特韦杂质; Caboteavir (GSK1265744) :卡替拉韦; Caboteavir (Standd)卡博特韦(Standd); 卡博特韦自由酸; 卡博格韦; 卡替拉韦相关杂质; Caboteavir (GSK1265744) 卡替拉韦,S7766; (3R,6S)-N-[(2,4-二氟苯基)甲基]-10-羟基-6-甲基-8,11-二羰基-4-氧杂-1,7-二氮杂三环[7.4.0.03,7]十三碳-9,12-二烯-12-甲酰胺; 13C,2H5]-卡博替拉韦; 13C,2H2,15N]-卡博替拉韦; 卡博特维; (3S,11-N-[(2,4-二氟苯基)甲基]-2,3,5,7,11,11A-六氢-6-羟基-3-甲基-5,7-二氧代恶唑并[3,2-A]吡啶并[1,2-D]吡嗪-8-甲酰胺; Caboteavir (GSK1265744) 卡替拉韦，S7766
• 英文别名: Caboteavir ,GSK744; S/GSK1265744; Cabotewei; Caboteavir; Caboteavir, 10 mM in DMSO; Caboteavin; (3S,11aR)-N-(2,4-Difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide; Caboteve; Cyclic pyranopterin; (3S,11-N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2; Caboteavir Free Acid; Caboteavir(GSK1265744A,GSK-744); SK744, GSK1265744; (3S,11-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexa; (3S,11-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CBOXAMIDE; 13C,2H2,15N]-Caboteavir; Caboteavir (GSK744, GSK1265744); (3R,6S)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-6-methyl-8,11-dioxo-4-oxa-1,7-diazatricyclo[7.4.0.03,7]trideca-9,12-diene-12-cboxamide; Caboteavir GSK744 GSK1265744 GSK-744; GSK1265744; GSK744; Caboteavir (GSK-1265744）; Caboteavir 13CD5; Caboteavir (GSK744, GSK1265744) //BP; GSK1265744A; GSK744 (S/GSK1265744); unii-hmh0132z1q; Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-cboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11); Cabotwe; (3S,11-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-cboxamide; Cabot wei

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 664.0±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇F₂N₃O₅
• 分子量: 405.352
• 闪点: 355.4±31.5 °C
• 精确质量: 405.113617
• PSA: 104.36000
• LogP: -1.70
• 外观性状: 粉末
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.661
• 储存条件: -20℃

生物活性

• 描述: Cabotegravir是一种有效的HIV整合酶抑制剂, 用于治疗和预防艾滋病毒感染, Cabotegravir抑制OAT1 (IC50为0.81 μM) 和OAT3 (IC50为0.41 μM)。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Reese MJ, Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2015 Sep 4:1-12.

  [2]. Reese MJ, et al. Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2015 Sep 4:1-12.

  [3]. Bowers GD, Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans. Xenobiotica. 2015 Jul 1:1-16.