1005-93-2

• 常用中文名：噬菌体
• 常用英文名：4-Ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide
• CAS号：1005-93-2
• 分子式：C₆H₁₁O₄P
• 分子量：178.123
• 相关类别： 信号通路 跨膜转运 GABA受体
• 发布时间：2016-03-28 23:14:13
• 更新时间：2024-01-04 20:15:59
• Etbicyphat(磷酸三甲基丙烷)是一种有效的GABA(a)受体竞争性拮抗剂。Etbicyphat在海马CA1神经元中诱导癫痫样活动,并与GABA(A)-苯二氮卓受体结合[1]。

名称

• 中文名: 噬菌体
• 英文名: 4-ethyl-2,6,7-trioxa-1λ5-phosphabicyclo[2.2.2]octane 1-oxide
• 英文别名: ETBICYPHAT; 1,1,1-Trimethylolpropane Phosphate; 4-Ethyl-2,6,7-trioxa-1-phospha-bicyclo<2,2,2>-octan-1-oxid; 4-ethyl-2,6,7-trioxa-1-phosphabicyclo<octane-1-oxide; TMP-P; Trimethyolpropane phosphate; 2,6,7-Trioxa-1-phosphabicyclo(2.2.2)octane, 4-ethyl-, 1-oxide (9CI); <1,1,1-Tris-hydroxymethyl-propan>-phosphorsaeureester; Ethyl Bicyclic Phosphate; Trimethylopropane phosphate; 4-Ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide; 2,6,7-Trioxa-1-phosphabicyclo[2.2.2]octane, 4-ethyl-, 1-oxide

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 213.1±7.0 °C at 760 mmHg
• 分子式: C₆H₁₁O₄P
• 分子量: 178.123
• 闪点: 96.9±38.5 °C
• 精确质量: 178.039490
• PSA: 54.57000
• LogP: 0.56
• 蒸汽压: 0.2±0.4 mmHg at 25°C
• 折射率: 1.467
• 储存条件: 室温，密封，干燥

生物活性

• 描述: Etbicyphat(磷酸三甲基丙烷)是一种有效的GABA(a)受体竞争性拮抗剂。Etbicyphat在海马CA1神经元中诱导癫痫样活动,并与GABA(A)-苯二氮卓受体结合[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 靶点:

  GABA(A)[1]

• 参考文献:

  [1]. Rijal SO, et al. Dissociation constants for GABA(A) receptor antagonists determined with neuronal networks on microelectrode arrays. J Neurosci Methods. 2008 Aug 30;173(2):183-92.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TY6475000 CHEMICAL NAME : 1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-, cyclic phosphate CAS REGISTRY NUMBER : 1005-93-2 LAST UPDATED : 199710 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C6-H11-O4-P MOLECULAR WEIGHT : 178.14 WISWESSER LINE NOTATION : T4PTJ AO BQ C2Q C1 DQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3080 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/m3/1H TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 960 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3550 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 182,1135,1973 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,207,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,149,1976

安全

• 危害码 (欧洲): Xi
• 海关编码: 2902199090

合成路线

824-11-3 ~% 1005-93-2

文献：Journal of the American Chemical Society, , vol. 84, p. 610 - 617

77-99-6 ~% 1005-93-2

文献：Journal of the American Chemical Society, , vol. 84, p. 610 - 617

3883-97-4 ~% 1005-93-2

文献：Journal of Organic Chemistry, , vol. 29, p. 3711 - 3712

10025-99-7 824-11-3 ~% 63372-08-7 1005-93-2

文献：Inorganic Chemistry, , vol. 23, p. 373 - 377

海关

海关编码	2902199090
中文概述	2902199090 其他环烷烃、环烯烃及环萜烯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:2.0%。普通关税:30.0%
申报要素	品名, 成分含量
Summary	2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%