140-65-8

• 常用中文名：丙吗卡因
• 常用英文名：pramocaine
• CAS号：140-65-8
• 分子式：C₁₇H₂₇NO₃
• 分子量：293.40100
• 发布时间：2018-07-25 13:50:36
• 更新时间：2024-02-05 18:55:51

名称

• 中文名: 丙吗卡因
• 英文名: pramocaine
• 英文别名: pramocainum; Pramocaine; Tronopthane; Proxazocain; 4-[3-(4-butoxyphenoxy)propyl]morpholine; Tronothane; pramoxine

物化性质

• 密度: 1.031g/cm3
• 沸点: 427ºC at 760 mmHg
• 分子式: C₁₇H₂₇NO₃
• 分子量: 293.40100
• 闪点: 123.5ºC
• 精确质量: 293.19900
• PSA: 30.93000
• LogP: 2.90450
• 蒸汽压: 1.7E-07mmHg at 25°C
• 折射率: 1.505
• 计算化学:

  1.疏水参数计算参考值（XlogP）:3.1

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:9

  5.互变异构体数量:无

  6.拓扑分子极性表面积:30.9

  7.重原子数量:21

  8.表面电荷:0

  9.复杂度:248

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD8575000 CHEMICAL NAME : Morpholine, 4-(3-(p-butoxyphenoxy)propyl)- CAS REGISTRY NUMBER : 140-65-8 BEILSTEIN REFERENCE NO. : 0239059 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C17-H27-N-O3 MOLECULAR WEIGHT : 293.45 WISWESSER LINE NOTATION : T6N DOTJ A3OR DO4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 38,265,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 38,265,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 79 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 10,291,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9141 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 153 (estimated) No. of Female Employees: 150 (estimated)

安全

• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%