80473-92-3

• 常用中文名：(6A,11B,16A,17A)-6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸
• 常用英文名：6a,9a-Difluoro-11b,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-carbothioic acid
• CAS号：80473-92-3
• 分子式：C₂₁H₂₆F₂O₄S
• 分子量：412.49100
• 发布时间：2019-01-01 20:44:37
• 更新时间：2026-08-05 10:07:57

名称

• 中文名: (6a,11b,16a,17a)-6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸
• 英文名: 6a,9a-Difluoro-11b,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-carbothioic acid
• 中文别名: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11,17-二羟基-10,13,16-三甲基-3-氧亚基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊二烯并[A]菲-17-羧硫代 S-酸; 6Α,9Α-二氟-11Β,17Α-二羟基-16Α-甲基-3-氧代雄甾-1,4-二烯-17Α-硫代羧酸; 氟替卡松杂质32; 硫代氟米松酸; 氟替卡松中间体 FT5; 氟替卡松杂质41异构体
• 英文别名: Fluticasone Impurity 41 Isomer; Androsta-1,4-diene-17-cbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-Methyl-3-oxo-, (6a,11b,16a,1; (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-cbothioic S-acid; (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro- 14,17dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]htadeca-3,6-diene-14-cbothioic S-acid; (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-cbothioic acid; "6a,9a-Difluoro-11β,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17a-cbothioic Acid"; Fluticasone intermediate F2; Axon; Fluticasone Thioacid; Fluticasone Impurity 41; Androsta-1,4-diene-17-cbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a); Noradrenaline Impurity 45; 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17a-cbothioic acid; Taletrectinib Impurity8; Androsta-1,4-diene-17- cbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-Methyl-3- oxo-,(6α,11β,16α,17α); Androsta-1,4-diene-17-cbothioic acid, 6,9-difluoro; (8S,10S,11S,13S)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-cbothioic S-acid; 6a,9a-Difluoro-11b,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-cbothioic acid; (6α,11,16α,17α); 6a,9a-Difluoro-11b,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17a-cbothioic Acid; (8S,10S,11S,13S)-6,9-difluoro-11,17-dihydroxy-10,13,16-trime; 11,17-dihydroxy-16-methyl-3-oxo-,(6α,11β,16α,17α)

物化性质

• 密度: 1.364g/cm3
• 沸点: 550.003ºC at 760 mmHg
• 熔点: 230-231°C
• 分子式: C₂₁H₂₆F₂O₄S
• 分子量: 412.49100
• 闪点: 286.431ºC
• 精确质量: 412.15200
• PSA: 109.85000
• LogP: 3.16770
• 折射率: 1.59
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi

合成路线

28416-82-2 ~92% 80473-92-3

文献：Zheng, Jin; Lai, Qinglin; Dai, Yiru; Zhao, Qingjie; Shen, Jingshan Organic Preparations and Procedures International, 2008 , vol. 40, # 6 p. 566 - 566

709002-84-6 ~% 80473-92-3

文献：WO2004/52912 A1, ; Page 30-31 ;

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